Correlation Between Early Myocardial Injury and Intestinal Flora Changes Associated With Oncology Drug Therapy
Overview
- Phase
- Not Applicable
- Intervention
- Antitumor drugs
- Conditions
- Cancer Therapy-related Cardiovascular Toxicity
- Sponsor
- Peking University Third Hospital
- Enrollment
- 50
- Locations
- 1
- Primary Endpoint
- At least a 10% decrease in the global longitudinal strain
- Status
- Recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
The purpose of this study was to explore the relationship between early myocardial injury caused by tumor drug therapy and intestinal microbial structure changes by echocardiographic two-dimensional speckle tracking technique and intestinal microflora structure detection.
Detailed Description
This is a monocentric prospective cohort study in which 50 patients treated for malignant tumors will be included. All participants will be followed for 6 months after the initiation of oncology drug therapy. Echocardiography and 2D speckle tracking will be performed and stool and blood samples will be tested before treatment initiation and at 3 and 6 months after initiation.
Investigators
Eligibility Criteria
Inclusion Criteria
- •With malignant tumors
- •Will receive antitumor drugs
- •Could receive regular follow-up for 6 months
- •Written informed consent
Exclusion Criteria
- •Satisfactory echocardiographic images could not be obtained
- •Cardiomyopathy
- •Coronary artery disease
- •Heart failure
- •Arrhythmia requiring intervention
- •Moderate or severe valvular disease
- •Acute myocarditis
- •Refractory hypertension
- •Participating in other studies of drug intervention
Arms & Interventions
Patients treated with antineoplastic agents
50 patients treated with antineoplastic agents will be enrolled.
Intervention: Antitumor drugs
Outcomes
Primary Outcomes
At least a 10% decrease in the global longitudinal strain
Time Frame: 6 months
The primary endpoint is at least a 10% decrease in the global longitudinal strain, determined using cardiac 2D STE and compared with baseline.