The Analysis of Endocrine-exocrine Functions and Prognosis After Pancreatectomy
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 入组人数
- 3,500
- 试验地点
- 1
- 主要终点
- postoperative pancreatic endocrine-exocrine functions
研究概览
简要总结
Pancreatic diseases often require surgery or invasive procedures to provide a chance for a cure. However, due to the pancreas's unique anatomical structure, its relative position to adjacent organs, and its dual endocrine and exocrine functions, the complexity of surgery is increased, impacting the patient's postoperative quality of life. Therefore, this project aims to retrospectively collect basic data, preoperative and postoperative blood tests (blood cell counts, biochemistry, tumor markers, glucose-related, lipid-related), and preoperative and postoperative imaging examinations (CT, MRI, Ultrasound, PET scan, Endoscopy, etc.) of patients who underwent pancreatic surgery at our hospital. We aim to compare whether surgical methods, lesion margin clearance rates, and postoperative remnant pancreatic volume affect the patient's endocrine function, exocrine function, quality of life, and disease prognosis. This analysis is intended to understand the indications, surgery-related factors, and prognosis for patients planning to undergo pancreatic surgery, with the expectation of providing more diverse and specific treatment recommendations for patients with pancreatic diseases in the future
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 20 Years 至 75 Years(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •All patients scheduled for pancreatectomy
排除标准
- •Age under 20 years or older than 75 years; Pregnancy
研究组 & 干预措施
pancreatectomy group
干预措施: pancreatectomy (Procedure)
结局指标
主要结局
postoperative pancreatic endocrine-exocrine functions
时间窗: 6 months after pancreatectomy
1. Pancreatic endocrine function will be measured by incidence of appearance of new-onset or aggravated DM after operation. 2. pancreatic exocrine function will be measured by incidence of appearance of steatorrhea which can be alleviated by replacement of digestive enzyme.
次要结局
未报告次要终点
研究者
National Taiwan University Clinical Trial Center
Clinical Professor
National Taiwan University Hospital
