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临床试验/NCT07396662
NCT07396662招募中不适用

The Analysis of Endocrine-exocrine Functions and Prognosis After Pancreatectomy

National Taiwan University Hospital1 个研究点 分布在 1 个国家目标入组 3,500 人开始时间: 2016年1月1日最近更新:
适应症
干预措施

试验速览

阶段
不适用
状态
招募中
入组人数
3,500
试验地点
1
主要终点
postoperative pancreatic endocrine-exocrine functions

研究概览

简要总结

Pancreatic diseases often require surgery or invasive procedures to provide a chance for a cure. However, due to the pancreas's unique anatomical structure, its relative position to adjacent organs, and its dual endocrine and exocrine functions, the complexity of surgery is increased, impacting the patient's postoperative quality of life. Therefore, this project aims to retrospectively collect basic data, preoperative and postoperative blood tests (blood cell counts, biochemistry, tumor markers, glucose-related, lipid-related), and preoperative and postoperative imaging examinations (CT, MRI, Ultrasound, PET scan, Endoscopy, etc.) of patients who underwent pancreatic surgery at our hospital. We aim to compare whether surgical methods, lesion margin clearance rates, and postoperative remnant pancreatic volume affect the patient's endocrine function, exocrine function, quality of life, and disease prognosis. This analysis is intended to understand the indications, surgery-related factors, and prognosis for patients planning to undergo pancreatic surgery, with the expectation of providing more diverse and specific treatment recommendations for patients with pancreatic diseases in the future

研究设计

研究类型
Observational
观察模型
Cohort
时间视角
Retrospective

入排标准

年龄范围
20 Years 至 75 Years(Adult, Older Adult)
性别
All
接受健康志愿者

入选标准

  • All patients scheduled for pancreatectomy

排除标准

  • Age under 20 years or older than 75 years; Pregnancy

研究组 & 干预措施

pancreatectomy group

干预措施: pancreatectomy (Procedure)

结局指标

主要结局

postoperative pancreatic endocrine-exocrine functions

时间窗: 6 months after pancreatectomy

1. Pancreatic endocrine function will be measured by incidence of appearance of new-onset or aggravated DM after operation. 2. pancreatic exocrine function will be measured by incidence of appearance of steatorrhea which can be alleviated by replacement of digestive enzyme.

次要结局

未报告次要终点

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

National Taiwan University Clinical Trial Center

Clinical Professor

National Taiwan University Hospital

研究点 (1)

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