Investigation of the effect of Trimetazidine in patients with Aluminum phosphide poisoning

Phase 3

• Conditions: Patients with Aluminum phosphide poisoning.; Poisoning by unspecified drugs, medicaments and biological substances, accidental (unintentional); T50.901

• Registration Number: IRCT20211017052794N1
• Lead Sponsor: Shahid Beheshti University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 2 May 2022

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: 30

Inclusion Criteria

Consumption of oral form of Aluminium phosphide and referrs to Loghman Hospital under 24 hours and the presence of symptoms consistent with poisoning
Positive silver nitrate test
Carbon monoxide levels above 10 in non-smokers

Exclusion Criteria

Glomerular Filtration Rate(GFR) less than 30 (if available ),history of renal failure , history of liver failure , history of acute myocardial infarction, history of heart failure, history of congenital heart disease
Pregnancy and lactation
Refer to hospital after 24 hours

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Mortality. Timepoint: During hospitalization. Method of measurement: Death during admission.

Secondary Outcome Measures

Name	Time	Method
Admit duration. Timepoint: Period of time. Method of measurement: Daily chart.;Icu admission. Timepoint: Number of hospitalization days. Method of measurement: Daily chart.;Arrhythmia. Timepoint: Daily electrocardiogram/As long as the patient is being treated with trimetazidine. Method of measurement: Electrocardiogram.;Need for inotropic drugs. Timepoint: Number of hospitalization days. Method of measurement: Based on blood pressure less than 90 mmHg and inotrop drugs initiation recorded in the chart.;Left ventricle ejection fraction. Timepoint: Second day of admission. Method of measurement: Echocardiography.;Intubation. Timepoint: Hospital admission. Method of measurement: Number of intubation patients registered in the chart.