Echocardiography in Kids Intensive Care Decision Support

Completed

• Conditions: Fluid Responsiveness; Cardiac Output
• Interventions: Other: Ultrasound cardiac output measurement

• Registration Number: NCT01821742
• Lead Sponsor: Imperial College London

Brief Summary

A study to determine if echocardiographically derived parameters, plethysmographic variability index and pulse pressure variation predict fluid responsiveness in children on PICU.

Detailed Description

A study to determine if echocardiographically derived parameters, plethysmographic variability index and pulse pressure variation predict fluid responsiveness in children on PICU. These parameters will be measured pre and post fluid bolus in children prescribed fluid bolus therapy for clinical indications on the PICU. Children will be classified as responders (\>10% increase in cardiac output) and non responders (\<10% increase). Appropriate statistical tests will be performed to determine the most useful predictor of an increase in cardiac output following a fluid bolus.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study Start: 2013-03
• Study First Submitted: 2013-03-22
• Study First Submitted QC: 2013-03-29
• Study First Posted: 2013-04-01
• Primary Completion: 2013-07
• Study Completion: 2013-07
• Status Verified: 2019-07
• Last Update Submitted: 2019-07-03
• Last Update Posted: 2019-07-08

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 25

Inclusion Criteria

• Any ventilated child requiring fluid bolus therapy on the PICU for clinical indications

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Exclusion Criteria

• Arrythmia
• Intracardiac shunt

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Children requiring fluid bolus on PICU	Ultrasound cardiac output measurement	-

Primary Outcome Measures

Name	Time	Method
Fluid responsiveness	Immediate	10% increase in cardiac output following fluid bolus

Trial Locations

Locations (1)

Imperial College Healthcare NHS Trust; 🇬🇧 London, United Kingdom