to compare the effect of fentanyl in heamodymanic changes during laryngoscopy and intubation(general anaesthesia) in normotensive vs hypertensive patient

Phase 4

Conditions: Health Condition 1: null- patient under going surgery which requires general anasthesia

Registration Number: CTRI/2017/07/009103

Lead Sponsor: Department of Anaesthesiology Sir T Hospital Bhavnagar

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Open to Recruitment

Sex: Not specified

Target Recruitment: 100

Inclusion Criteria

NORMOTENSIVE PATIENT:

1Age:20 to 50 years

2Gender: Male and Female

3ASA physical status I and II

4Patient posted for elective surgery under general anaesthesia requiring endotracheal intubation

5Surgery duration less than two hours

6BMI <= 25kg/m2.

7Informed written consent for participation in study.

8Modified Mallampatti Classification I and II

HYPERTENSIVE PATIENT:

1Age:20 to 50 years

2Gender: Male and Female

3ASA physical status II(well controlled primary

Idiopathic hypertension (blood pressure <= 140/90) with maximum three antihypertensive

medications excluding Î² blocker)

No end organ involvement due to hypertension.

4Patient posted for elective surgery under general anaesthesia requiring endotracheal intubation

5Surgery duration less than two hours

6BMI <= 25kg/m2.

7Informed written consent for participation in study.

8Modified Mallampatti Classification I and II

Exclusion Criteria

1Patient refusing consent

2Patient with Diabetes ,COPD, Renal disease, Cardiac diseases like IHD, Valvular heart disease, AV conduction block, LVF & Psychiatric illness etc.

3Patient on drugs likes sedatives, opioids, anti-psychiatrics and Î² blockers.

4ASA physical status III and above.

5Anticipated difficult intubation.

6BMI 25>=kg/m2

7Intubation attempt lasting more than 20seconds

8Patient on more than 3 antihypertensive medications.

9Defaulter of taking antihypertensive medication as per schedule

Study & Design

Study Type: Interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
To assess the efficacy and safety of fentanyl in attenuating hemodynamic stress response to laryngoscopy and endotracheal intubation in normotensive v/s controlled hypertensive patients in respect to following parameters: <br/ ><br> 1. Heart Rate (HR) <br/ ><br> 2. Systolic Blood Pressure (SBP) <br/ ><br> 3. Diastolic Blood Pressure (DBP) <br/ ><br> 4. Mean Arterial Pressure (MAP) <br/ ><br> 5. Change in cardiac rhythmTimepoint: base line-15 minute after premedication-5 minute after fentanyl-during laryngoscopy and intubation-after intubation(1,3,5,10,15,20,30,45,60,90,120 minute)-at the time of extubation-after extubation

Secondary Outcome Measures

Name	Time	Method
-To assess the sedative effect of fentanyl. <br/ ><br>-To observe complication if any in both groups. <br/ ><br>Timepoint: base line-15 minute after premedication-5 minute after fentanyl-during laryngoscopy and intubation-after intubation(1,3,5,10,15,20,30,45,60,90,120 minute)-at the time of extubation-after extubation