Effectiveness of subcutaneous Tranexamic acid injection and Hydroquinon cream in treatment of melasma
Phase 3
- Conditions
- Melasma.Chloasma
- Registration Number
- IRCT2015110324865N1
- Lead Sponsor
- Vice-Chancellor in Research Affairs of Shahid Beheshti University of Medical Science
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 52
Inclusion Criteria
Every patient between 20-50 years old that do not use any topical treatment for melasma at least 1 month before the trial and have epidermal melasma with wood 's lamp and do not have exclusion criteria.
Exclusion criteria: Pregnancy and lactation; Dermal melasma; Using any treatment for melasma during 1 month ago; Using OCP or any hormonal or phototoxic drugs.
Exclusion Criteria
Not provided
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Hyperpigmentation homogeneity. Timepoint: Before intervention,4 weeks and 8 weeks after begining of the intervention and 4 weeks ater the end of the intervention. Method of measurement: MASI score.;Area involved. Timepoint: before intervention,4weeks and 8 weeks after begining of the intervention and 4 weeks ater the end of the intervention. Method of measurement: MASI score.;Darkness of pigment compared with normal skin. Timepoint: before intervention,4weeks and 8 weeks after begining of the intervention and 4 weeks ater the end of the intervention. Method of measurement: MASI score.
- Secondary Outcome Measures
Name Time Method Erythema. Timepoint: 4 weeks and 8 weeks after beginning of the intervention and 4 weeks after the end of the intervention. Method of measurement: Asking the patient.;Irritation. Timepoint: 4 weeks and 8 weeks after beginning of the intervention and 4 weeks after the end of the intervention. Method of measurement: asking the patient.;Dryness. Timepoint: 4 weeks and 8 weeks after beginning of the intervention and 4 weeks after the end of the intervention. Method of measurement: Asking the patient.;Alergic reaction. Timepoint: 4 weeks and 8 weeks after beginning of the intervention and 4 weeks after the end of the intervention. Method of measurement: Asking the patient.