The reno-protective effect of intraoperative dexmedetomidine infusion in cardiopulmonary bypass machine facilitated open heart surgery in patients with preexisting renal impairment

Phase 4

• Conditions: renoprotective effect; Dexmedetomidine; Cardiopulmonary Bypass; Acute Kidney Injury; Morbidity; Mortality; Renal Replacement Therapy; NGAL protein, human; Postoperative Complications

• Registration Number: TCTR20160601006
• Lead Sponsor: Faculty of Medicine, Chulalongkorn University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Study Start: 2016-06-01
• Study Completion: 2017-04-01
• Last Update Posted: 19 August 2024

Recruitment & Eligibility

• Status: Pending (Not yet recruiting)
• Sex: All
• Target Recruitment: 20

Inclusion Criteria

1. Patients undergoing elective CPB-facilitated
open heart surgery
2. Age > 18 years old
3. eGFR < 60 mL/min but ≥ 30 mL/min

Exclusion Criteria

1. Allergy to any drugs in study
2. Previous surgery in thoracic cavity
3. Severe cardiac dysfunction (LVEF <30%)
4. BMI > 35 kg/m2

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Acute Kidney Injury at surgical incision, 6 hour, 48 hour, 24 hour, 48 hour postoperatively urine NGAL

Secondary Outcome Measures

Name	Time	Method
ength of ICU and hospital stay postoperative Counting the time spent in ICU and hospital admission,Surgical comnplicaition Postopertive describe the postoperative complication,Renal replacement therapy postoperative 24 hours describe type and time if any renal replacement thearpy required