A Follow-up of the Influencing Factors of Dyskinesia in Patients With Parkinson's Disease
试验速览
- 阶段
- 不适用
- 入组人数
- 300
- 试验地点
- 1
- 主要终点
- the occurrence of dyskinesia and its related predicting factors
研究概览
简要总结
Parkinson' patients who have not had dyskinesia would be observed for 2 years in a multicenter prospective study with the purposes to clarify the predicting factors of dyskinesia.
详细描述
Parkinson' patients with daily levodopa dosage above 200mg and no dyskinesia would be recruited into the study. They would be observed for two years for analyzed the predicting factors of dyskinesia. At the baseline, demographic information, Clinical information, blood sample, picture of tongure coating would be collected at the baseline. All participants were evaluated every three months for two years. The severity of motor symptoms were evaluated every 6 months.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients have been clinically diagnosed with Parkinson disease at the recruitment.
- •Patients have received Levodopa treatment with the daily dosage above 200mg.
排除标准
- •be suspicious of atypical Parkinson or other Parkinson syndrome. 2) have experienced dyskinesia. 3) incorporation to the investigation
结局指标
主要结局
the occurrence of dyskinesia and its related predicting factors
时间窗: The data would be analyzed within 9 months of the study completion. The outcome would be reported within 1 year of the the study completion.
to evaluate the occurrence of dyskinesia during the 2 years of follow-up and identify its predicting factors of dyskinesia
次要结局
- to evaluate patients ' living quality and the severity of non motor symptoms during the 2 years of follow-up(The data would be analyzed within 9 months of the study completion. The outcome would be reported within 1 year of the the study completion.)