Influence of Central Sensitization on Efficacy of Patient-controlled Epidural Analgesia in Osteoarthritis Patients Undergoing Total Knee Replacement

• Conditions: Knee Osteoarthritis
• Interventions: Procedure: CSI score < 40; Procedure: CSI score ≥ 40

• Registration Number: NCT01863342
• Lead Sponsor: Yonsei University

Brief Summary

Nociceptor inputs can trigger a prolonged but reversible increase in the excitability and synaptic efficacy of neurons in central nociceptive pathways, the phenomenon of central sensitization. The degenerative joint disease, osteoarthritis, with characteristic destruction of cartilage and alteration in bone is a very common cause of chronic pain. The degree of pain does not always correlate with the extent of joint damage or presence of active inflammation raising the possibility that there may be a central component to the pain. The central sensitization inventory (CSI) is a new self-report screening instrument to measure the degree of central sensitization, and to help identify patients with central sensitivity syndromes. The aim of this investigation is to evaluate the influence of preoperative central sensitization, which represented by CSI score, on postoperative pain score in osteoarthritis patients undergoing total knee replacement who receiving patient-controlled epidural analgesia.

Detailed Description

Not available

Study Timeline

• Status Verified: 2013-05
• Study Start: 2013-05
• Study First Submitted: 2013-05-22
• Study First Submitted QC: 2013-05-22
• Last Update Submitted: 2013-05-22
• Study First Posted: 2013-05-27
• Last Update Posted: 2013-05-27
• Primary Completion: 2014-05
• Study Completion: 2014-05

Recruitment & Eligibility

• Status: UNKNOWN
• Sex: All
• Target Recruitment: 98

Inclusion Criteria

• Aged 20 to 80 years osteoarthritis patients undergoing total knee replacement under spinal anesthesia, and who receiving postoperative epidural PCA

Exclusion Criteria

• refusal
• coagulopathy
• neurologic deficit
• preoperative opioids medication
• recent analgesics change

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
CSI score < 40	CSI score < 40	CSI cutoff value\<40
Group 2: CSI score ≥ 40	CSI score ≥ 40	CSI cutoff value≥40

Primary Outcome Measures

Name	Time	Method
Peak pain score	at the point of Epidural PCA to postoperative 1-48 h	Numeric rating scale (0 to 10 points) at each assessment interval

Trial Locations

Locations (1)

Department of Anesthesiology and Pain Medicine, Yonsei University College of Medicine; 🇰🇷 Seoul, Korea, Republic of