Laparoscopy in Children: Does it Decrease the Metabolic, Endocrine and Inflammatory Stress Response to Surgery

Not Applicable

Completed

• Conditions: Gastro-Oesophageal Reflux

• Registration Number: NCT00231543
• Lead Sponsor: Institute of Child Health

Brief Summary

The aim of this trial was to characterise the intra and post operative metabolic, endocrine and inflammatory response to laparoscopic fundoplication in children. We are testing the hypothesis that laparoscopic fundoplication is associated with a lack of hypermetabolism and catabolism and blunting of the endocrine/inflammatory stress response

Detailed Description

Not available

Study Timeline

• Status Verified: 2005-10
• Study First Submitted: 2005-10-03
• Study First Submitted QC: 2005-10-03
• Study First Posted: 2005-10-04
• Last Update Submitted: 2006-10-11
• Last Update Posted: 2006-10-12

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

• infants and children with gastro-oesophageal reflux

Exclusion Criteria

• septic shock, multi-organ dysfunction syndrome, cardiac, renal or congenital metabolic abnormalities

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Primary Outcome Measures

Name	Time	Method
resting energy expenditure

Secondary Outcome Measures

Name	Time	Method
whole body protein turnover
indices of inflammatory response
pro and anti inflammatory cytokines
free radical production
post operative pain

Trial Locations

Locations (1)

Great Ormond Street Hospital and the Institute of Child health; 🇬🇧 London, United Kingdom