Raman spectroscopy and colorectal cancer

Completed

• Conditions: Colorectal cancer; Cancer

• Registration Number: ISRCTN37247461
• Lead Sponsor: Abertawe Bro Morgannwg University Health Board

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Completion: 2017-12-31
• Study Start: 2018-01-03
• Last Update Posted: 12 February 2018

Recruitment & Eligibility

• Status: Completed
• Sex: All
• Target Recruitment: 150

Inclusion Criteria

1. Aged 50 years or over at time of presentation to GP symptoms/signs raising suspicion of CRC:
1.1. Rectal bleeding and change of bowel habit (looser stool/increased frequency persisting for 6 weeks
1.2. Rectal bleeding alone without anal symptoms or change in bowel habit persisting for 6 weeks
1.3. Change in bowel habit alone (looser stools/increased frequency) without rectal bleeding persisting for 6 weeks
1.4. Unexplained iron deficiency anaemia, haemoglobin of <110 g/l in men; OR unexplained iron deficiency anaemia, haemoglobin of <100 g/l in non-menstruating women
2. Able and willing to give informed consent to participate
3. Willing to provide a fasting blood sample
4. Willing to grant researchers access to identifiable data to enable result feedback to GP; 1. Aged 50 years or over at time of presentation to GP symptoms/signs raising suspicion of CRC:
1.1. Rectal bleeding and change of bowel habit (looser stool/increased frequency persisting for 6 weeks
1.2. Rectal bleeding alone without anal symptoms or change in bowel habit persisting for 6 weeks
1.3. Change in bowel habit alone (looser stools/increased frequency) without rectal bleeding persisting for 6 weeks
1.4. Unexplained iron deficiency anaemia, haemoglobin of <110 g/l in men; OR unexplained iron deficiency anaemia, haemoglobin of <100 g/l in non-menstruating women
2. Able and willing to give informed consent to participate
3. Willing to provide a fasting blood sample
4. Willing to grant researchers access to identifiable data to enable result feedback to GP

Exclusion Criteria

1. Patients in whom a secondary care referral is considered mandatory in the opinion of the GP (e.g. clinically detected rectal or abdominal mass)
2. Patients with a prior history of CRC or other invasive malignancy within the last 5 years
3. Patients with signs/symptoms which require emergency referral to secondary care or A&E (e.g. intestinal obstruction, peritonitis, massive haemorrhage)
4. Patients with genetic conditions associated with CRC (Lynch syndrome and familial adenomatous polyposis)
5. Patients with known inflammatory bowel disease
6. Patient from vulnerable groups; 1. Patients in whom a secondary care referral is considered mandatory in the opinion of the GP (e.g. clinically detected rectal or abdominal mass)
2. Patients with a prior history of CRC or other invasive malignancy within the last 5 years
3. Patients with signs/symptoms which require emergency referral to secondary care or A&E (e.g. intestinal obstruction, peritonitis, massive haemorrhage)
4. Patients with genetic conditions associated with CRC (Lynch syndrome and familial adenomatous polyposis)
5. Patients with known inflammatory bowel disease
6. Patient from vulnerable groups

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
The proportion of recruited patients who are referred on the USC pathway within the intervention group and compared to the control group at 12 months;The proportion of recruited patients who are referred on the USC pathway within the intervention group and compared to the control group at 12 months