EFFECTS OF EXTRACORPOREAL CYTOKINE ELIMINATION ON HEMODYNAMIA AND MORTALITY IN CRITICAL PATIENTS
试验速览
- 阶段
- 不适用
- 状态
- Enrolling By Invitation
- 发起方
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- The time to resolution of vasoplegic shock within days.
研究概览
简要总结
Observation of the effects of cytokine adsorbent hemadsorption therapy on hemodynamics and mortality in critically ill patients who developed vasoplegic shock due to hyperinflammation without microbiological findings in the intensive care unit.
详细描述
Observation of the effects of cytokine adsorbent hemadsorption therapy on hemodynamics and mortality in critically ill patients who developed vasoplegic shock due to hyperinflammation without microbiological findings and met the inclusion criteria in the Intensive Care Unit between 01.08.2023 and 01.02.2024
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •C-reactive protein (CRP) ≥ 100 mg/l
- •Procalcitonin (PCT) < 2 ng/l
- •Patients aged 18-80 years who were treated with cytokine adsorption due to vasoplegic shock
排除标准
- •Patients under 18 years of age
- •Patients with suspected or proven bacterial cause of vasoplegic shock.
- •Those who did not approve to participate in the study
- •Patients without vasoplegic shock
- •Patients with CRP < 100 mg/l, PCT ≥ 2 μg/L
结局指标
主要结局
The time to resolution of vasoplegic shock within days.
时间窗: From enrollment to the end of treatment at 12 weeks
次要结局
- 7-day mortality(7 days)
- mortality until discharge from hospital(From enrollment to the end of treatment at 12 weeks)
- Interleukin 1 beta level on day 1(one day)
- mechanical ventilation need and duration(From enrollment to the end of treatment at 12 weeks)
- duration of treatment in the intensive care unit(From enrollment to the end of treatment at 12 weeks)
- TNF - α level on day 1(one day)
- Interleukin 10 level on day 1(one day)
- Interleukin 6 level on day 1(one day)
- Interleukin 1 beta level on day 3(3 days)
- Interleukin 10 level on day 3(3 days)
- Interleukin 6 level on day 3(3 days)
- TNF - α level on day 3(3 days)
- dose of catecholamine(From enrollment to the end of treatment at 12 weeks)
研究者
Hakan Küçükkepeci
Principal Investigator
Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization