JPRN-UMIN000003419已完成未知
Study on cardiac sympathetic nerve function in the diagnosis of dementia with Lewy bodies and Alzheimer's disease - Research project of DLB diagnossis
Department of Neurology and Neurobiology of Aging, Kanazawa University School of Medical Science0 个研究点目标入组 140 人开始时间: 2010年4月5日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 140
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 55years-old 至 85years-old（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •(1) Exclusion criteria related to I-123 MIBG caridac scintigrphy Excluded are the conditions affecting I-123 MIBG myocardial accumulation as shown below: 1. The patient taking tricyclic antidepressants and/or reserpine. 2. The patient having cardiac failure. 3. The patient having ischemic heart disease within six months to participate in this study. 4. The patient having myocardial blood flow SPECT abnormalities within one year to participate in this study. 5. The patient planning surgeries of major arteries including revascularization within 2 months to participate in this study. 6. The patient having poorly controlled NIDDM [HbA1c >7.0%] or insulin therapy. 7. The patient having severe kidney dysfunction or renal failure [eGFR<15 mL/min/1.73m2]. 8. The patient having hemodialysis. 9. The patient having pheochromocytoma. 10. The patient having amyloid neuropathy or other obvious peripheral neuropathy. 11. The patient having history of neoplasm within five years to participate in this study. 12. The patient having pregnant, nursing or probability of pregnancy. (2) Other exclusion criteria 1. Parkinson's disease, cerebral infarction which affects cognitive function, Huntington disease, normal pressure hydrocephalus, brain tumor, progressive supranuclear palsy, epilepsy, subdural hematoma, multiple sclerosis, head injury with aftereffect. 2. The patient having infection or focal regions revealed by MRI such as cerebral infarction which affects cognitive function. 3. The patient having cardiac pacemaker, aneurysm clip, prosthetic valve, cochlear implant, or other metal implants. 4. The patient having history of alcohol or drug abuse, sever disease or unstable disease, deficiency of vitamin B12 or folic acid, syphilis, or thyroid dysfunction. 5. The case judged by clinical evaluation committee as inappropriate.
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