Enhancing Sonographic Measurement of Intraneural Blood Flow in the Median Nerve
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 20
- 试验地点
- 4
- 主要终点
- Change in intraneural blood flow after intervention
研究概览
简要总结
Carpal tunnel syndrome (CTS) is the most common nerve compression disease and the most expensive upper-extremity work-related musculoskeletal disorder, affecting approximately 10 million people in the US. To understand the clear etiology and mechanism of carpal tunnel syndrome, the measurement of median nerve intraneural blood flow needs to be further scrutinized as the common fluctuating physiological conditions and functional hand activities might contribute to the fluctuation of the measurement and serve as measurement error. This study aims to examine how intraneural blood flow within the median nerve is affected by physiological factors (i.e., body temperature and blood pressure) and functional hand activities (i.e., typing, using a mouse, and cooking).
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Basic Science
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Aged 18 to 65
- •English-speaking
- •Ability to endure a moderate-intensity physical activity
- •Ability to type without looking at the keyboard
排除标准
- •Pain, tingling, or numbness in the hand or wrist region within the past week
- •History of corticoid injection in the upper extremity
- •History of surgery in the wrist region
- •Carpal tunnel syndrome
- •Amyotrophic lateral sclerosis
- •Hypothyroidism
- •Positive Phalen's test
- •Persistent median artery within wrist region
- •Bifid median nerve
结局指标
主要结局
Change in intraneural blood flow after intervention
时间窗: Immediately prior to and after each intervention
Doppler ultrasound images will be repeatedly collected to obtain the primary outcome measure for this study, intraneural blood flow. After identifying the course of the median nerve in the longitudinal plane (I.e., the sagittal plane), intraneural blood flow at the level of carpal tunnel measured as the peak systolic velocity of the identified blood flow signal will be observed and collected.
次要结局
未报告次要终点
研究者
Shawn Roll
Associate Professor
University of Southern California