Modified HFNC Therapy for ARF Patients Undergoing Flexible Bronchoscopy

Not Applicable

Recruiting

• Conditions: High-flow Nasal Cannula Oxygen; Acute Hypoxemic Respiratory Failure
• Interventions: Device: Modified HFNC oxygen therapy; Device: Face mask

• Registration Number: NCT05759832
• Lead Sponsor: Beijing Chao Yang Hospital

Brief Summary

Acute respiratory failure (AFR) is a serious condition that requires prompt and appropriate intervention to prevent further deterioration and improve outcomes. Bronchoscopy is a commonly used diagnostic and therapeutic procedure in patients with respiratory failure. However, traditional low-flow oxygen supplementation during bronchoscopy may not provide adequate oxygenation and ventilation, leading to complications and worsening of the patient's condition.

High-flow nasal cannula therapy has improved oxygenation and ventilation in critically ill patients, making it a promising alternative to traditional oxygen supplementation during bronchoscopy. The bronchoscope is passed through the nose during all procedures in our center. HFNC oxygen therapy is applied to both nostrils. The bronchoscope occupies one of the nares receiving oxygen therapy during bronchoscopy. As a result, the application of HFNC needs to be optimized. Therefore, the investigators designed a modified HFNC with a single cannula. However, limited data exist on the safety and efficacy of modified HFNC therapy in patients with respiratory failure undergoing bronchoscopy.

Therefore, the aim of this study is to evaluate the impact of modified HFNC therapy on the outcomes of undergoing bronchoscopy in patients with ARF. The findings of this study will contribute to understanding the role of modified HFNC therapy in managing ARF and inform clinical practice.

Detailed Description

Not available

Study Timeline

• Study First Submitted: 2023-02-27
• Study First Submitted QC: 2023-02-27
• Study First Posted: 2023-03-08
• Study Start: 2023-04-01
• Status Verified: 2024-07
• Last Update Submitted: 2025-02-08
• Last Update Posted: 2025-02-11
• Primary Completion: 2025-09-30
• Study Completion: 2025-10-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 140

Inclusion Criteria

1. Age ≥ 18 years old;
2. Bronchoscopy is required;
3. 150 mmHg ≤ PaO2/FiO2 < 300 mmHg.

Exclusion Criteria

1. Not tolerate HFNC oxygen therapy;
2. Obstruction of nasopharynx cavity;
3. Platelet<60 × 109/L；
4. Need tracheal intubation;
5. The patient has received invasive ventilation.

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Modified HFNC oxygen therapy group	Modified HFNC oxygen therapy	-
Face mask group	Face mask	-

Primary Outcome Measures

Name	Time	Method
Need to increase ventilatory support	Within 24 hours after bronchoscopy	The proportion of patients needs to increase ventilatory support, including (1) upgrading respiratory support; (2) increasing parameters of non-invasive mechanical ventilation or modified HFNC.

Secondary Outcome Measures

Name	Time	Method
The incidence of hypoxia during bronchoscopy	During bronchoscopy	Hypoxia is defined as SpO2 \< 90%.

Trial Locations

Locations (1)

Beijing Chao-Yang Hospital; 🇨🇳 Beijing, Beijing, China