NCT04413305Unknown不适用
WGS-guided Tracking and Infection Control Measures of Carbapenem-resistant Klebsiella Pneumoniae
适应症
干预措施
试验速览
- 阶段
- 不适用
- 入组人数
- 1,000
- 试验地点
- 1
- 主要终点
- Evaluate the influence of WGS-based screen and control measures on the CRKP occurrence rate
研究概览
简要总结
The objective of this study is to investigate the effect of the infection control measures based on the active screening of carbapenem-resistant Klebsiella pneumoniae and whole-genome based tracking and surveillance though the hospital.
研究设计
- 研究类型
- Interventional
- 分配方式
- Non Randomized
- 干预模型
- Parallel
- 主要目的
- Screening
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 80 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •The patient was admitted to the ICU of neurosurgery in the west hospital of huashan hospital affiliated to fudan university from September 2019 to September 2021, or transferred from the ICU of another hospital
- •The patient is more than 18 years old and less than 80 years old, regardless of gender.
- •Informed consent of the patient;
排除标准
- •Patients participating in other clinical trials at the same time
- •4. People who will affect the outcome of the study: whose specimens could not be received or not enough for testing
研究组 & 干预措施
WGS-based screen and control group
Experimental
For intervention group, we screen admitted patients for carbapenem-resistant Klebsiella pneumoniae and carry out 'Bundle' infection and control measures. When outbreak or tranmission of CRKP was observed, we take whole-genome sequencing to track origin and transmission route to decease CRKP rate.
干预措施: screen of CRKP and infection control measure (Other)
Non-intervention
No Intervention
Non-intervention
结局指标
主要结局
Evaluate the influence of WGS-based screen and control measures on the CRKP occurrence rate
时间窗: 2 years
次要结局
- Analysis of transmission pattern and route pre and post WGS-based tracking(2 years)
研究者
研究点 (1)
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