Incidence of Ventilator-Associated Pneumonia, it’s Clinico-Microbiological profile & Antibiotic Sensitivity Patterns inMechanically Ventilated ICU Patients

Not yet recruiting

Brief Summary: Type of Study: Prospective Observational Study.

Objective: To determine the incidence, clinical and microbiological profile, and antibiotic sensitivity patterns of ventilator-associated pneumonia (VAP) in ICU patients.

Background

VAP is the most common hospital acquired infection in ICU settings.

In India, gram-negative resistant organisms are increasingly responsible for VAP.

Despite growing antimicrobial resistance, VAP epidemiology in India remains underreported.

Aims and Objectives

1. Assess VAP incidence in mechanically ventilated ICU patients.

2. Analyze clinical presentation, microbiological findings, and antibiotic sensitivity.

3. Evaluate clinical response and ICU course.

Methodology

Study Setting: Three ICUs in Sanjay Gandhi Postgraduate Institute of Medical Sciences (SGPGI): Main Post Op ICU, Apex Trauma Centre ICU, PMSSY ICU.

Sample: Minimum of 100 adult ICU patients intubated for more than 48 hours.

Exclusions: Patients from outside SGPGI, immunocompromised, or with pre-existing lung conditions (pneumonia, ARDS, CHF).

ETT Culture Timeline: Within 24 hours of intubation.

Between 72–96 hours.

Biweekly thereafter ( after 96 hours).

Recruitment & Eligibility

Inclusion Criteria

Adult patients of both gender staying in ICU for more than 48 hours after endotracheal intubation.

Exclusion Criteria

Negative consent.
Patients admitted to ICU with ETT in situ prior admission.
Patients who are immunocompromised and or on immunosuppressant drugs.
Patients with pre-existing pneumonia, aspiration pneumonitis, ARDS, pulmonary edema and CHF.

Primary Outcome Measures

Name	Time	Method
To study the incidence of VAP and its microbiological profiling from the endotracheal isolate of mechanically ventilated ICU patients.	24 hours , 72 to 96 hours , after 96 hours twice weekly sampling

Secondary Outcome Measures

Name	Time	Method
1.To find out the antibiotic susceptibility and sensitivity patterns of the microorganisms isolated and identified in our study.	2.To determine different risk factors in critically ill ICU patients who are on mechanical ventilator support with respect to VAP (Ventilator Associated Pneumonia).

Locations (1): Sanjay Gandhi Postgraduate Institute of Medical Sciences
🇮🇳
Lucknow, UTTAR PRADESH, India
Sanjay Gandhi Postgraduate Institute of Medical Sciences
🇮🇳Lucknow, UTTAR PRADESH, India
Dr Esha Kujur
Principal investigator
8884963766
esha.v.kujur@gmail.com
Dr Puneet Goyal
Principal investigator
8004904597
princeofcoma@yahoo.co.uk