NCT05540262招募中不适用
Edaravone in the Treatment of Optic Neuritis
First Affiliated Hospital of Guangxi Medical University1 个研究点 分布在 1 个国家目标入组 50 人开始时间: 2022年1月15日最近更新:
适应症
干预措施
相关药物
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 50
- 试验地点
- 1
- 主要终点
- Best-corrected visual acuity
研究概览
简要总结
Edaravone has demonstrated a beneficial effect in promoting remyelination and protecting axons in animals with NMOSD. The researchers posit that edaravone may enhance visual outcomes in patients with aquaporin-4 antibody-positive optic neuritis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Chinese patients aged ≥18 with anti-aquaporin-4 antibody-positive optic neuritis
- •Patients with a first episode of optic neuritis in either eye
- •First symptoms of optic neuritis ≤30 days prior to the first administration of edaravone
排除标准
- •Myopia over 6 diopters
- •Refractive media opacity affecting assessment of retinal layers and/or visual acuity
研究组 & 干预措施
Edaravone
Experimental
干预措施: Edaravone (Drug)
结局指标
主要结局
Best-corrected visual acuity
时间窗: 18 months
Best-corrected visual acuity will be measured by "Illiterate E"chart.
次要结局
- Ganglion cell-inner plexiform layer(18 months)
- Peripapillary retinal nerve fiber layer(18 months)
研究者
Yi Du
Dr.
First Affiliated Hospital of Guangxi Medical University
研究点 (1)
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