Evaluation of the effect of empagliflozin on prevention of atrial fibrillation after heart surgery
Phase 2
Recruiting
- Conditions
- Atrial fibrillation after heart surgery.Paroxysmal atrial fibrillation
- Registration Number
- IRCT20120520009801N9
- Lead Sponsor
- Mashhad University of Medical Sciences
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 160
Inclusion Criteria
Candidates for heart surgery including CABG or valve replacement
70 yr > age > 18 yr
Taking ACEIs/ARBs, beta-blockers, statins and aspirin for CABG patients
Exclusion Criteria
History of taking empagliflozin drug before surgery
Severe heart failure (NYHA Class IV)
Renal failure (30 = GFR)
Hepatic failure (hepatic enzymes > 3 times of upper normal limit )
pregnancy
Have pacemaker
Have AF rhythm
History of heart surgery
Very thin people (BMI = 18.5 kg/m2)
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The incidence of atrial fibrillation. Timepoint: Through 72 hrs after heart surgery. Method of measurement: Holter monitoring.
- Secondary Outcome Measures
Name Time Method C-Reactive Protein (CRP) blood concentration. Timepoint: Before surgery and 3 days after surgery. Method of measurement: Laboratory.;The incidence of ventricular and supra-ventricular arrhythmias. Timepoint: Through 72 hrs after heart surgery. Method of measurement: Holter monitoring.;Lenght of hospital stay. Timepoint: From heart surgery to discharge. Method of measurement: Counting of hospitalizations days.