Comparison of Cervical Ultrasound and Echoscintigraphy for Preoperative Localization Diagnosis in Primary Hyperparathyroidism
试验速览
- 阶段
- 不适用
- 发起方
- CHU de Reims
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Adenoma parathyroid diagnosed using cervical ultrasound
研究概览
简要总结
The biological diagnosis of the primary hyperparathyroidism is now facilitated by the reliability of the balance of phosphate and calcium and the dosage of parathyroid hormone (PTH).
This diagnosis of preoperative localization is important as surgery are now targeted to the responsible lesion.
The "gold standard" for this localization is the cervical ultrasound exploring the usual sites of adenomas and a MIBI scintigraphy (the parathyroid adenoma significantly concentrating this cell marker).
However, the diagnosis of preoperative localization remains a subject of discussion as to the most appropriate tests. Indeed, the morphological diagnosis is performed at the ultrasound stage in more than half the cases. It is the new performance of this morphological examination that makes it possible to obtain these results.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Diagnostic
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —(Adult, Older Adult)
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients with primary hyperparathyroidism with surgery indication
- •Age > 18yo
排除标准
- •surgical contraindication
- •medical treatment by cinacalcet
- •non sporadic hyperparathyroidism
- •Age <18yo
- •Protected by the law
研究组 & 干预措施
Patients
干预措施: cervical ultrasound (Other)
结局指标
主要结局
Adenoma parathyroid diagnosed using cervical ultrasound
时间窗: Day 0
Adenoma parathyroid diagnosed using cervical ultrasound. Cervical ultrasound will be realized by a endocrinologist trained in the cervical ultrasound and not informed of the results of the echoscintigraphy
Adenoma parathyroid diagnosed using echoscintigraphy
时间窗: Day 0
Adenoma parathyroid diagnosed using echoscintigraphy. Echoscintigraphy will be realized by a nuclear physician not informed of the results of the cervical ultrasound
Adenoma parathyroid diagnosed using anatomopathology
时间窗: Day 0
Adenoma parathyroid diagnosed by anatomopathologist, after surgery.
次要结局
未报告次要终点
