Oral Flora, Periodontitis, and Vascular Dysfunction in Young Native Americans.
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 92
- 试验地点
- 1
- 主要终点
- Determination of bacterial populations in periodontal samples before and after standard periodontal treatment, stratified by severity of gum disease, using microbial metagenomics analysis.
研究概览
简要总结
We propose to examine a population of Native Americans who have had little or no dental care, and to determine if periodontal disease is associated with early signs of vascular dysfunction or systemic inflammation. We then propose to treat the periodontitis and re-evaluate vascular function. We will determine if gingivitis or mild/moderate periodontitis is associated with detectable vascular dysfunction. Microbial metagenomics will be correlated with vascular function.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 21 Years 至 40 Years（Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •American Indian/Alaskan Natives seeking health care at the Indian Health Council, Inc.
- •Males and females aged 21-40 years.
- •Exclusion criteria:
- •Recent (within 6 months) periodontal treatment
- •History of high blood pressure or existing heart disease
- •Xerostomia
- •Currently receiving treatment for cancer
- •Currently taking anti-inflammatory medications (except H2 blockers, statins, or medications that can affect periodontal status
- •Immunosuppressed due to medication or HIV infection, or presence of active infection such as hepatitis or tuberculosis
- •Fewer than 20 teeth in functional dentition, excluding third molars, or other gross oral pathology
排除标准
- 未提供
结局指标
主要结局
Determination of bacterial populations in periodontal samples before and after standard periodontal treatment, stratified by severity of gum disease, using microbial metagenomics analysis.
时间窗: Time of enrollment and at 6 week follow up visit
The study will assess if periodontal bacterial flora differ in patients with healthy gums, mild, or severe periodontal disease.
次要结局
未报告次要终点
研究者
Roberta A. Gottlieb
Director, SDSU BioScience Center
San Diego State University