α-N-acetylgalactosaminidase Levels in Panic Disorder: A Prospective Observational Cohort Study
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 发起方
- 入组人数
- 66
- 试验地点
- 1
- 主要终点
- α-N-acetylgalactosaminidase
研究概览
简要总结
This prospective observational cohort study investigated serum α-N-acetylgalactosaminidase levels in drug-naïve patients with Panic Disorder (PD) at baseline and after six weeks of follow-up and compared them with healthy controls (HC). Associations between enzyme levels, symptom severity, and inflammatory markers were examined. The study aimed to evaluate whether α-N-acetylgalactosaminidase levels are associated with PD symptom severity and inflammatory parameters.
详细描述
Panic Disorder (PD) is associated with increased inflammatory markers. α-N-acetylgalactosaminidase mediates deglycosylation of vitamin D-binding protein (Gc protein), affecting macrophage activation and immune regulation. Its role in anxiety disorders has not been previously examined.
Thirty-three drug-naïve patients with PD and 33 healthy controls (HC) were enrolled. Patients with PD were evaluated at baseline and after six weeks of standard clinical treatment. Serum α-N-acetylgalactosaminidase levels were measured using ELISA. DSM-5 Panic Disorder Scale (PDS) scores and complete blood count inflammatory parameters were recorded.
No intervention was assigned as part of the research protocol. Participants received routine clinical care.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •For Panic Disorder (PD) Group:
- •Inclusion Criteria:
- •Age ≥18 years and <65 years
- •Diagnosis of PD according to DSM-5-TR
- •Drug-naïve at baseline
排除标准
- •Age <18 years and >65 years
- •Any psychiatric diagnosis other than PD
- •Active alcohol or substance use disorder
- •Significant medical illness
- •Incomplete follow-up
- •For Healthy Control (HC) Group:
- •Inclusion Criteria:
- •Age ≥18 years and <65 years
- •Exclusion Criteria:
- •Age <18 years and >65 years
- •Any psychiatric diagnosis
- •Active alcohol or substance use disorder
- •Significant medical illness
研究组 & 干预措施
Panic Disorder (PD)
Drug-naïve adult participants (18-65 years) diagnosed with Panic Disorder according to DSM-5-TR criteria. Participants were evaluated at baseline and after 6 weeks of routine clinical treatment. No intervention was assigned by the study protocol. Blood samples were collected for measurement of serum α-N-acetylgalactosaminidase levels and inflammatory parameters. Clinical symptom severity was assessed using the DSM-5 Panic Disorder Scale (PDS).
干预措施: No intervention was assigned as part of the research protocol. (Other)
Healthy Control (HC)
Healthy control adult participants (18-65 years) without any current or past psychiatric disorder. No intervention was administered as part of the research protocol. Participants underwent a baseline clinical evaluation and provided a single blood sample for measurement of serum α-N-acetylgalactosaminidase levels and complete blood count inflammatory markers.
干预措施: No intervention was assigned as part of the research protocol. (Other)
结局指标
主要结局
α-N-acetylgalactosaminidase
时间窗: Baseline and 6 weeks
Serum α-N-acetylgalactosaminidase levels measured by ELISA (ng/mL).
次要结局
- DSM-5 Panic Disorder Scale (PDS) Score(Baseline and 6 weeks)
- Logistic regression prediction of PD diagnosis(Baseline)
- α-N-acetylgalactosaminidase and neutrophil count correlation(Baseline)
- α-N-acetylgalactosaminidase and neutrophil count association(Baseline)
研究者
Mehmet Hamdi ÖRÜM
Associate Professor
Elazığ Mental Health and Diseases Hospital