Prevention of Graft Reinfection After Liver Transplantation With Anti HCV Monoclonal Antibodies Identified in Chronically Infected Patients or in Patients With Resolved Hepatitis C
- Conditions
- Hepatitis C
- Registration Number
- NCT00638144
- Lead Sponsor
- University Hospital, Strasbourg, France
- Brief Summary
End stage HCV-related cirrhosis has become a major indication for liver transplantation (LT). Unfortunately, recurrence of HCV infection on the liver graft occurs in almost all patients following transplantation and causes a persistent infection that leads to chronic hepatitis and cirrhosis in a significant proportion of patients. To date there is no effective way to prevent HCV reinfection of the liver graft in the early phase after transplantation. . Early passive immunotherapy with neutralizing antibodies against HCV should be considered for preventing reinfection of liver transplanted patients associated with HCV. This approach is well established in the case of patients undergoing liver transplantation for chronic hepatitis B virus infection. Our purpose is to produce neutralizing monoclonal antibodies to prevent reinfection of the liver graft.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 300
- Health insurance
- Resolved HCV infection ( HCV RNA negative since more then 6 months ) -HCV chronically infected ( RNA positive )
- Anti- HCV antibodies positive
- Volunteers and informed patients
- Immunosuppression
- HBV or HIV infection
- Pregnancy
- Breast feeding
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (3)
Service de Chirurgie Générale et Transplantation Multiorganes - Hôpital de Hautepierre
🇫🇷Strasbourg, France
Service d'Hépato-Gastro-Entérologie - Hôpital Civil
🇫🇷Strasbourg, France
Service d'Hématologie et Oncologie - Hôpital de Hautepierre
🇫🇷Strasbourg, France