Influence of Thymoglobuline on Phenotypic and Functional Profiles of B Lymphocytes in Renal Transplant Recipients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 49
- 试验地点
- 4
- 主要终点
- The distribution of mature blood B cells subpopulations will be compared between the 2 groups
研究概览
简要总结
The investigators expect to better characterise B cell subpopulation and functional properties early after graft, to analyse effect of induction therapy (thymoglobulin versus basiliximab) on B cells, and to compare this B cell profiles with those obtained in our previous study in patients with chronic Antibody Mediated Rejection (cAMR)
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age >18 years old
- •Recipient of a renal allograft
- •Patient receiving either basiliximab or thymoglobulin as in induction therapy for renal transplant
- •Patient presenting a low immunologic risk
- •Patient not opposed to his (her) study participation
排除标准
- •Patient participating in a clinical trial
研究组 & 干预措施
Thymoglobulin Induction
Patient receiving thymoglobulin as an induction therapy for renal transplant
干预措施: Thymoglobulin Induction (Drug)
Basiliximab Induction
Patient receiving basiliximab as an induction therapy for renal transplant
干预措施: Basiliximab Induction (Drug)
结局指标
主要结局
The distribution of mature blood B cells subpopulations will be compared between the 2 groups
时间窗: one year after renal transplant
Proliferation of freshly isolated cells T in presence of autologous B cells will be compared between the 2 groups.
时间窗: one year after renal transplant
次要结局
- Serum B-cell activating factor (BAFF) concentration comparison between the two groups(one year after renal transplant)