Heterogeneity in Association of Heart Rate and Initial Presentation of Cardiovascular Diseases Using Linked Electronic Health Records
试验速览
- 阶段
- 不适用
- 入组人数
- 1,961,286
- 试验地点
- 1
- 主要终点
- Risk of atherosclerotic disease in patients with high or low heart rate
研究概览
简要总结
Study of heterogeneity in associations between heart rate and the initial presentation of 12 cardiovascular diseases.
详细描述
This study is part of the CALIBER (Cardiovascular disease research using linked bespoke studies and electronic records) programme funded over 5 years from the NIHR and Wellcome Trust. The central theme of the CALIBER research is linkage of the Myocardial Ischaemia National Audit Project (MINAP) with primary care (GPRD) and other resources. The overarching aim of CALIBER is to better understand the aetiology and prognosis of specific coronary phenotypes across a range of causal domains, particularly where electronic records provide a contribution beyond traditional studies. CALIBER has received both Ethics approval (ref 09/H0810/16) and ECC approval (ref ECC 2-06(b)/2009 CALIBER dataset).
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Retrospective
入排标准
- 年龄范围
- 30 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •One year prior to study entry (up-to-standard follow-up, CPRD quality research standard).
- •> 30 years old
- •have at least a recorded heart rate measurement during the study period
排除标准
- •Evidence of prior atherosclerotic or cardiac disease
结局指标
主要结局
Risk of atherosclerotic disease in patients with high or low heart rate
时间窗: Participants were followed until the first Coronary disease event (an expected average of 5 years)
Hazard ratios will be also presenting associations between heart rate and initial presentation of different cardiovascular diseases. These associations will be also measured between different levels of heart rate and CVDs stratified by: * by sex * gender * a range of risk factors (such as physical activity, smoking status, drinking status, etc.)
次要结局
- Incidence proportions and life time risk for Cardiovascular diseases(Participants were followed until the first Coronary disease event (an expected average of 5 years))
研究者
Harry Hemingway
Professor
University College, London