The effect of personalized perioperative blood pressure management on intraoperative cerebral oxygen saturation, burst suppression ratio and postoperative neurological outcomes in patients having major surgery: an observational substudy of the IMPROVE-pilot trial
- Conditions
- euromonitoring and postoperative neurological outcome in patients participating in the IMPROVE pilot trial which investigates intraoperative personalized blood pressure managmentI95Hypotension
- Registration Number
- DRKS00025762
- Lead Sponsor
- Zentrum für Anästhesiologie und Intensivmedizin, Universitätsklinikum Hamburg-Eppendorf
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 55
Age = 45
- American Society of Anesthesiologists physical status class (ASA) II-IV
- scheduled for elective major surgery under general anesthesia
- surgery expected to last = 120 minutes
- emergency surgery
- patients having liver or kidney transplantation
- pregnancy
- status of post transplantation of kidney, liver, heart, or lung
- sepsis (according to current Sepsis-3 definition)
- impossibility of preoperative automated blood pressure monitoring
- MAP differences between the right and the left arm of more than 20 mmHg surgery that requires controlled hypotension
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Primary exploratory endpoint: Referred to the individual preoperative baseline value, the integral of NIRS value and time (area under the curve). <br>The NIRS regional tissue oxygen saturation (rSO2) will be assessed using Masimo Sedline Monitoring. Before induction of anesthesia, non-invasive NIRS electrodes will be placed on the patient’s forehead to monitor cerebral regional oxygen saturation. The treating anesthesiologist will be blinded to the NIRS-Monitoring.
- Secondary Outcome Measures
Name Time Method
Related Research Topics
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