To compare and evaluate the depth of penetration and postoperative pain using various irrigants in root canal treatment.

Not yet recruiting

• Conditions: Other and unspecified diseases ofpulp and periapical tissues,

• Registration Number: CTRI/2025/03/083128
• Lead Sponsor: Its Dental college hospital and research centre

Brief Summary

This study compares two different irrigation protocols in root canal treatment to assess their effectiveness in irrigant penetration and post-operative pain:

Patient selection:

Patients are diagnosed and randomly divided into two groups:

Group 1**:** Sequential chelation with 2.5% NaOCl and 17% EDTA.

Group 2:  Continuous chelation with 9% HEDP + 2.5% NaOCl.

Root canal procedure:

Patients are anesthetized, isolated with a rubber dam, and canals are accessed and prepared with ProTaper Next instruments.

Both groups receive irrigation after each file: Group 1 with NaOCl and EDTA, Group 2 with NaOCl and HEDP.

Final irrigation steps differ between groups, with Group 1 using NaOCl and EDTA, and Group 2 using HEDP + NaOCl and saline.

Irrigant penetration evaluation:

After final irrigation, 1 ml of radio-opaque dye is injected into the canal and a radiograph is taken to evaluate the irrigant penetration.

Post-operative procedure:

After drying the canals, the tooth is temporarily sealed, and patients return for obturation and post-operative restoration.

Pain evaluation:

Post-operative pain is recorded at 6, 24, and 48 hours using the NRS pain scale. If pain persists, patients are prescribed an escape drug and excluded from the study.

This study aims to determine which irrigation method provides better irrigant penetration and reduces post-operative pain.

Detailed Description

Not available

Study Timeline

• Study Start: 2025-01-04
• Last Update Posted: 2025-10-03

Recruitment & Eligibility

• Status: Not Yet Recruiting
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• 1.Adult patients aged between 18-30 years.
• 2.Adult permanent symptomatic anterior or posterior teeth requiring treatment.
• 3.Pain at NRS scale above 4 cm level.
• 4.Feasibility of isolation of the tooth with a rubber dam.
• 5.Participants with the ability to understand the consent forms.

Exclusion Criteria

• Perforation cases 2.
• Periodontally compromised tooth.
• Patients not willing for the treatment 4.
• Patients allergic to iodine.
• Non-negotiable canals.

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
1. To evaluate and compare the apical depth penetration using 9% HEDP in combination with Sodium hypochlorite (NaOCl) with the standard irrigating protocol (17% EDTA + NaOCl) using sonic irrigation technique in symptomatic vital teeth.	after procedure

Secondary Outcome Measures

Name	Time	Method
To evaluate and compare the post-operative pain using 9% HEDP in combination with Sodium hypochlorite (NaOCl) with the standard irrigating protocol (17% EDTA + NaOCl) using sonic irrigation technique in symptomatic vital teeth.	Post operative pain will be checked after 6, 24 and 48 hours.

Trial Locations

Locations (1)

ITS Dental College Hospital and Research Centre Greater Noida; 🇮🇳 Nagar, UTTAR PRADESH, India

ITS Dental College Hospital and Research Centre Greater Noida

🇮🇳Nagar, UTTAR PRADESH, India

Dr Shohrat Iqbal

Principal investigator

9810976792

shohrat.mds24@its.edu.in