Behavioral Activation (BA) for Medication-responsive Chronically Depressed Patients With Impaired Social Functioning
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Persistent Depressive Disorder
- Sponsor
- New York State Psychiatric Institute
- Enrollment
- 16
- Locations
- 1
- Primary Endpoint
- Paid Work Hours at Week 12
- Status
- Completed
- Last Updated
- 8 years ago
Overview
Brief Summary
The investigators aimed to assess the ability of a modified version of Behavioral Activation for occupational and social improvement to produce change in: 1. social adjustment, 2. work functioning, 3. avoidance behavior and 4. behavioral activation.
Detailed Description
Psychosocial functioning was assessed before and after BA treatment in medication responsive depressed individuals who continued to have impaired social functioning. The primary goal was to demonstrate feasibility of recruitment and retention, and obtain an open pilot sense as to whether there are benefits from this brief psychotherapy approach in this population. The investigators also planned to refine measures and estimate the effect size of any treatment response to estimate power and sample size with the goal of completing a future controlled study.
Investigators
Eligibility Criteria
Inclusion Criteria
- •adults aged 20-75 years
- •a primary diagnosis of Dysthymic Disorder, Chronic major depressive disorder or double depression
- •a \>50% decrease in 17 item Hamilton Rating Scale for Depression (HRSD-17) score and a final HRSD-17 score ≤ 10 with an adequate antidepressant medication (ADM) trial (\> 4 weeks on at least 50% Physician's Desk Reference maximum ADM dose)
- •a rating of 1 ("very much improved") or 2 ("much improved") on the Clinical Global Impressions-Improvement scale (CGI-I)
- •continued functional impairment, defined by scores \>1.9 on the Social Adjustment Scale (SAS)
- •unemployment (jobless, looking for work) according to the Bureau of Labor Statistics: jobless and looking and available for work, or underemployed.
Exclusion Criteria
- •Structured Clinical Interview for Diagnostic and Statistical Manual, fourth edition (DSM-IV) Axis I disorders-diagnosed cognitive or psychotic disorders
- •bipolar disorder
- •active eating disorders
- •severe borderline personality disorder
- •alcohol or drug dependence (except nicotine) in the last 6 months
- •current suicide risk
- •unstable medical conditions
- •use of psychotropic medications other than antidepressants
Outcomes
Primary Outcomes
Paid Work Hours at Week 12
Time Frame: Week 12
Subject-reported paid work hours per week at week 12
Paid Work Hours at Week Baseline
Time Frame: Baseline
Subject-reported paid work hours per week at week baseline
Secondary Outcomes
- Social Functioning at Week Baseline on the Social Adjustment Scale(baseline)
- Social Functioning at Week 12 on the Social Adjustment Scale(Week 12)