Effect of Different Levels Positive End-Expiratory Pressure on the Incidence of Atelectasis After Heart Surgery

Vice Chancellor for research Mazandaran University of Medical Sciences.0 个研究点目标入组 180 人开始时间: 待定最近更新: 2018年2月22日

适应症

试验速览

暂无简介。

•The inclusion criteria including: Patients candidate for non emergency open heart surgery (coronary artery bypass and heart valve surgery by sternotomy and cardiopulmonary bypass); Aged from 18 until 65 years; No ejection fraction less than 30% in the angiography form, preoperative; No history of chronic airway obstruction disease and lung trauma; No history of open heart surgery or lung surgery; No history of rib fractures and chest tube insertion; No history of trauma in the head or nose, neurologic disease and frequent sinus infections; No history of chemotherapy and using immunosuppressants three months prior to the surgery; No serum creatinine greater than 3.5 mg/Dl; No body mass index greater than 40 kg/m2; Consciousness level at 15 before surgery;
•Exclusion criteria including: Arterial systolic pressure less than 90 mmHg despite of fluid intake; Arterial blood pH less than 7.30; Arterial carbon dioxide pressure greater than 50 mmHg; Arterial oxygen saturation less than 80% despite of supplemental oxygen intake; Hemoglobin concentration less than 7 gr/dL; Aortic cross clamp time longer than 150 minutes; Cardiopulmonary bypass time longer than 240 minutes; Using intra aortic balloon pump (IABP) intraoperative and postoperative; Intubation over 24 hours; Also, the patient will be excluded from the study when he/she retransfers to the operating room or when he/she needs ventilator therapy protocols apart from of research protocols.

发起方

Vice Chancellor for research Mazandaran University of Medical Sciences.