Microsatellite instability in colorectal carcinoma, and its association with Programmed Cell Death Ligand 1 (PD-L1) expression
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 1
- 主要终点
- 1.Proportion of cases of colorectal carcinoma with deficient mismatch repair (dMMR).
研究概览
简要总结
Colorectal carcinoma is one among the leading cause of cancer related deaths around the globe. Molecular heterogeneity plays an important role in predicting the prognosis and treatment outcome in patients with colorectal carcinoma, and to predict the feasibility of novel methods of anticancer therapy, hence becoming a potential subject for exploration and research.
This study is a cross sectional observation study on Microsatellite instability in colorectal carcinoma and it’s association with programmed cell death ligand 1 (PD-L1) expression that will be conducted in Department of pathology, Maulana azad medical college, New Delhi, India. The primary outcome measures will be proportion of cases of colorectal carcinoma with deficient mismatch repair (dMMR) and those showing PD-L1 expression. The secondary outcomes will be association of MSI status with clinicopathological parameters.
The reporting magnitude of colorectal carcinoma among the population and its update is very important in country like India with a population of morethan 1.4 billion.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 99.00 Year(s)（—）
- 性别
- All
入选标准
- •Newly diagnosed and Histologically confirmed cases of colorectal carcinoma.
排除标准
- •Patients who have recieved prior chemotherapy/immunotherapy.
结局指标
主要结局
1.Proportion of cases of colorectal carcinoma with deficient mismatch repair (dMMR).
时间窗: Baseline
2.Proportion of cases of colorectal carcinoma showing PD-L1 expression
时间窗: Baseline
次要结局
- 1.Association of MSI status and immunohistochemical expression of PD-L1 with clinicopathological parameters(Baseline)
研究者
Dr Muhammed Yaseen O P
Maulana Azad Medical College