ACTRN12618000908235
Recruiting
N/A
The efficacy of rehabilitation on motor function in individuals with hereditary cerebellar ataxia. A randomised controlled trial.
Murdoch Children's Reseach Institute0 sites80 target enrollmentMay 30, 2018
Overview
- Phase
- N/A
- Intervention
- Not specified
- Conditions
- Not specified
- Sponsor
- Murdoch Children's Reseach Institute
- Enrollment
- 80
- Status
- Recruiting
- Last Updated
- 3 years ago
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •1\. Have a molecular diagnosis or at least three generations affected, of a recessive or dominant inherited cerebellar ataxia.
- •2\. Aged over 15 years
- •3\. A minimum score of 2 for question 1: Gait of the Scale for the Assessment and Rating of Ataxia (SARA) \[2 \= Gait clearly abnormal, tandem walking \> 10 steps not possible].
- •4\. A minimum score of 4 for item I: Transfers Bed, Chair, Wheel\-chair of the Functional Independence Measure \[4 \= Minimal Assistance, the participant completes 75% or more of the task].
- •5\. Given clearance by cardiologist or other appropriate medical professional for participation in rehabilitation and the hydrotherapy component.
- •6\. Able to give informed consent.
Exclusion Criteria
- •1\. Individuals with non\-genetic ataxia or non\-degenerative ataxia.
- •2\. Musculoskeletal injury limiting ability to weight\-bear.
- •3\. Another medical condition not related to their hereditary cerebellar ataxia that impacts on mobility.
- •4\. Undergone major orthopaedic surgery in the last six months.
- •5\. Need for immediate intensive intervention for safety reasons.
- •6\. Pregnancy.
- •7\. Dementia or significant cognitive impairment limiting ability to give informed consent and participate in the rehabilitation program.
- •8\. Received botulinum toxin injections for spasticity management (except for regular longstanding paraspinal botulinum injections \- this is defined as at least two doses of botulinum injections in the same muscle/s within eight months of the screening period).
- •9\. Already completing greater than three hours per week physical exercise/therapy focused on the lower limb (i.e. pilates, personal trainer, home exercise program, independent gym program, exercise physiology) or is participating in a structured goal\-based physiotherapy rehabilitation program. This does not include physical activity that occurs as part of the person's daily life, i.e. walking to the shops.
- •10\. Currently enrolled in a clinical trial or planned enrolment in a clinical trial during the period of the study.
Outcomes
Primary Outcomes
Not specified
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