The efficacy of rehabilitation on motor function in individuals with hereditary cerebellar ataxia. A randomised controlled trial.

Murdoch Children's Reseach Institute0 个研究点目标入组 80 人开始时间: 2018年5月30日最近更新: 2022年6月13日

适应症

试验速览

暂无简介。

•1. Have a molecular diagnosis or at least three generations affected, of a recessive or dominant inherited cerebellar ataxia.
•2. Aged over 15 years
•3. A minimum score of 2 for question 1: Gait of the Scale for the Assessment and Rating of Ataxia (SARA) [2 = Gait clearly abnormal, tandem walking > 10 steps not possible].
•4. A minimum score of 4 for item I: Transfers Bed, Chair, Wheel-chair of the Functional Independence Measure [4 = Minimal Assistance, the participant completes 75% or more of the task].
•5. Given clearance by cardiologist or other appropriate medical professional for participation in rehabilitation and the hydrotherapy component.
•6. Able to give informed consent.

•1. Individuals with non-genetic ataxia or non-degenerative ataxia.
•2. Musculoskeletal injury limiting ability to weight-bear.
•3. Another medical condition not related to their hereditary cerebellar ataxia that impacts on mobility.
•4. Undergone major orthopaedic surgery in the last six months.
•5. Need for immediate intensive intervention for safety reasons.
•6. Pregnancy.
•7. Dementia or significant cognitive impairment limiting ability to give informed consent and participate in the rehabilitation program.
•8. Received botulinum toxin injections for spasticity management (except for regular longstanding paraspinal botulinum injections - this is defined as at least two doses of botulinum injections in the same muscle/s within eight months of the screening period).
•9. Already completing greater than three hours per week physical exercise/therapy focused on the lower limb (i.e. pilates, personal trainer, home exercise program, independent gym program, exercise physiology) or is participating in a structured goal-based physiotherapy rehabilitation program. This does not include physical activity that occurs as part of the person's daily life, i.e. walking to the shops.
•10. Currently enrolled in a clinical trial or planned enrolment in a clinical trial during the period of the study.
•11. Has a medical condition that precludes entry into a hydrotherapy pool, including bowel incontinence.

发起方

Murdoch Children's Reseach Institute