Comparing Anterior Segment Parameters During Pregnancy and Post-Pregnancy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- Corneal thickness
研究概览
简要总结
The aim of this study is to evaluate anterior segment changes during and after pregnancy, and compare them with non pregnant healty women
详细描述
Pregnancy is a physiological process in which many systems such as cardiovascular, pulmonary, renal, hematological and visual systems are affected, especially the endocrine system. Many organs, including the eye and orbit, are affected by the physiological interaction between the fetus and the mother. In most pregnant women, these effects are at the physiological level and are temporary; Sometimes it can be pathological and permanent. Hormonal, coagulative and hemodynamic changes are responsible for most of the ocular adaptations. Changes in corneal curvature, sensitivity and thickness are observed during pregnancy. It has been reported that corneal curvature increases with pregnancy, this increase occurs in the last trimester and returns to first trimester values at the end of the breastfeeding period. Although the etiology of this steepening of the cornea has not been clearly clarified, it is thought that it may be due to corneal edema caused by hormonal changes. However, it's not recommended for pregnant women to prescribe contact lenses because their variable keratometric values. A decrease in corneal sensitivity during pregnancy has been detected by esthesiometry in many studies. It decreases especially in the third trimester and returns to normal around the 2nd month after delivery. The corneal thickness measured by pachymeter may increase in pregnant women. some of them had myopic shift. In a study, 83 pregnant women were examined to determine the causes of visual disturbances during pregnancy and postpartum period. Previous studies reported that there was a change in favor of myopia (-0.9±0.3D) during pregnancy and it returned to pre-pregnancy levels in the postpartum period. Unstable refractions were thought to be due to changes in corneal thickness and curvature.
As a result, it was stated that the refractive change was temporary and in favor of myopia. It is recommended to wait up to several weeks postpartum before prescribing new eyeglasses [8].
There are various reports about IOP in normal pregnant women. In most of these studies, a decrease was found in IOP during pregnancy. In a prospective study, a decrease in IOP was found in the second and third trimesters of pregnancy, and it was shown that this change returned in the first month postpartum.
Before planning an anterior segment surgeries such as cataract and refractive surgery, changes in pregnancy should be taken into account and attention should be paid to surgical timing. The aim of this study is to reveal whether there is a change in anterior segment parameters in pregnancy period
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Prospective
入排标准
- 年龄范围
- 19 Years 至 40 Years(Adult)
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Ages between 20-40 years
- •Pregnant women with a gestational age less than 14 weeks in the first examination
- •Having no systemic disease before and during pregnancy
- •Having a spherical refractive error of less than 4 diopters, and/or had a cylindrical refractive error of less than 2 diopters
排除标准
- •Having systemic disease, having ocular pathology that may decrease visual acuity
- •Usage of systemic drugs or topical ocular drops
- •Usage of exogenous hormones and entered menopause
结局指标
主要结局
Corneal thickness
时间窗: 40 weeks
Corneal thickness in mikrometer value
Anterior chamber volume
时间窗: 40 weeks
Anterior chamber volume in mm3
Auto refractometer
时间窗: 40 weeks
Refractive error measurement in diopter
Axial length
时间窗: 40 weeks
Axial length in mm
Anterior chamber depth
时间窗: 40 weeks
Anterior chamber depth in mm
Anterior chamber angle
时间窗: 40 weeks
Anterior chamber angle in degree
Mean keratometry
时间窗: 40 weeks
in Diopters
Anterior flat keratometry
时间窗: 40 weeks
in Diopters
Steep keratometry
时间窗: 40 weeks
in Diopters
Tonometry
时间窗: 40 weeks
İntraocular pressure measurement in mmHg
Best corrected visual acuity assessment
时间窗: 40 weeks
Snellen and logMAR chart
Blood pressure measurement
时间窗: 40 weeks
Systemic blood pressure
Lens power
时间窗: 40 weeks
in diopters
次要结局
未报告次要终点
研究者
Çisil Erkan Pota
Medical Doctor
Akdeniz University
