Identification and characterization of the latent HIV-infected reservoir in long-term anti-retroviral therapy (ART) suppressed patients
Completed
- Conditions
- HIV-infectioninfection with human immunodeficiency virus10047438
- Registration Number
- NL-OMON43932
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 8
Inclusion Criteria
The intended participants are eight HIV-infected UMC Utrecht patients and part of the CHEESE cohort. The patients in the CHEESE cohort were among the first HIV patients in the Netherlands on effective ART (1997), and the intended subset of eight patients has previously (2005) donated a large blood draw (METC-04017). At that time-point, after 8 years of effective therapy, HIV DNA could still be detected in these patients. Now, 10 years later, we would like to re-approach these patients to donate a large blood draw, which will allow us to longitudinally assess in more detail if and in which T-cell subsets HIV can reside.
Exclusion Criteria
Unability to undergo a large blood draw in the opinion of the treating physician.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method