Analysis of the effect of tricyclic antidepressants for herpes zoster pain or post herpetic neuralgia for the QTc interval on electrocardiogram.
Not Applicable
- Conditions
- herpes zoster pain, post herpetic neuralgia
- Registration Number
- JPRN-UMIN000008757
- Lead Sponsor
- Osaka City University Graduate School of Medicine
- Brief Summary
Eighty-seven patients were analysed. The analgesic dosages of TCAs significantly prolonged QTc interval(delta QTc, 6.7 +- 16.1 ms). Although 15 patients were categorized as having abnormal QTc prolongation, there were no dangerous cases such as QTc > 500 ms or delta QTc > 60 ms. In multivariate logistic analysis, Left ventricular hypertrophy was detected as independent risk factor for abnormal QTc prolongation (OR 4.09; 95% CI 1.01-16.55, p=0.04).
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 100
Inclusion Criteria
Not provided
Exclusion Criteria
Patients who were administered other antipsychotic or anti-arrhythmic agents, and who have any rhythm disturbance on the electrocardiogram (ECG) before medication.
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method QTc interval before and after the administration of TCAs.
- Secondary Outcome Measures
Name Time Method age, gender, the type and dose of administered TCAs, medication periods