Analysis of Cardiac Biomarkers, Electrocardiograms and Cardio-pulmonary Exercise Test (CPET) Results in Children With Dilated (DCM), Hypertrophic (HCM) and Left-ventricle Non-compaction (LVNC) Cardiomyopathies
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Cardiomyopathies
- Sponsor
- Katarzyna Łuczak-Woźniak
- Enrollment
- 80
- Locations
- 1
- Primary Endpoint
- Assessment of ECG (electrocardiographic) differences in children with cardiomyopathies and healthy children.
- Last Updated
- 3 years ago
Overview
Brief Summary
The aim of the study is to analyze cardiac biomarkers, electrocardiograms and cardio-pulmonary exercise test (CPET) results in children with cardiomyopathies.
Detailed Description
The study group will consist of children that have been diagnosed with DCM, HCM or LVNC. The control group will be composed of healthy children. Examination of cardiac biomarkers (in the study group), ECG, 24-hour- ECG monitoring, CPET will be performed. Patients in the study group will be invited for 2 consecutive visits (in 6-10 months intervals). During the first and the last visit CPET will be performed. The control group will not be invited for consecutive visits.
Investigators
Katarzyna Łuczak-Woźniak
MD, Department of Pediatric Cardiology and General Pediatrics, Medical University of Warsaw, Warsaw, Poland.
Medical University of Warsaw
Eligibility Criteria
Inclusion Criteria
- •Children with HCM, DCM, LVNC diagnosed in 2D echo.
- •Healthy children with no congenital heart disease (CHD) in 2D echo.
- •Patients who signed consent form.
Exclusion Criteria
- •Patients with coexisting CHD, kidney and liver disfunction, taking anti-psychotic and anti-depressant medication, or patients with bundle bunch blocks in ECG.
- •no consent form signed.
Outcomes
Primary Outcomes
Assessment of ECG (electrocardiographic) differences in children with cardiomyopathies and healthy children.
Time Frame: 14 months
Assessment of heart rhythm, heart rate (BPM), PQ, QRS, QT, QTc intervals, QRS-T angle and arrythmia in ECG. These will be compared with arrythmia severity in 24-hour ecg monitoring.
Assessment of differences in CPET results in children with cardiomyopathies and healthy children.
Time Frame: 14 months
Assessment of peak respiratory oxygen uptake (peakVo2), carbon dioxide production (Vco2), anaerobic threshold (AT), expired ventilation (VE), ventilatory equivalent for CO2 (VE/VCO2), VO2/Work rate relationship, maximal workload (W), duration of exercise (T).
Secondary Outcomes
- Assessment of progression of heart failure in children with cardiomyopathies(20 months)
- Assessment of arrhythmia in time in children with cardiomyopathies(20 months)
- Assessment of changes in CPET results in children with cardiomyopathies(20 months)