An integrated optimization of Surgery and radioTherApy techniques to impRove cosmetic outcome and quaLity of life In breast conserviNG therapy for breaSt cancer patient
- Conditions
- Breast cancer
- Registration Number
- NL-OMON22078
- Lead Sponsor
- Erasmus MC
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- Not specified
- Target Recruitment
- 750
•Female patients aged = 18 years
•History of BCT with adjuvant radiation therapy for non-metastatic, histologically proven invasive breast cancer (pT1-3N0-2a) or DCIS. In light of BCT adjuvant systemic treatment (i.e. endocrine therapy, chemotherapy and immune therapy) is allowed.
•Breast conserving surgery between 1st of January 2016 and 31th of December 2018
•Treated according to the currently applied dose fractionation schedules, i.e. whole breast radiotherapy, with or without boost
•Adequate understanding of the Dutch language and written informed consent
•Any breast surgery or re-irradiation on the breast area after BCT
•Progression of disease (and additional treatment) since BCT
•Patients who received partial breast irradiation
• Current pregnancy or breast feeding
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method The primary focus of this project will be to determine which different combinations of (oncoplastic reconstructive) surgery and radiotherapy techniques, in the context of breast conserving therapy for (pre-invasive) breast cancer, contribute the most to the development of fibrosis.
- Secondary Outcome Measures
Name Time Method To assess the relation between the presence and severity of fibrosis, cosmetic outcome and different QoL domains and symptoms.