Comparative Study on the Efficacy of OliNano SEAL and Curodont D' Senz in Treatment of Dentin Hypersensitivity

Phase 4

Completed

• Conditions: Dentin Hypersensitivity
• Interventions: Drug: Olinanoseal; Drug: Curodont D'senz

• Registration Number: NCT05122312
• Lead Sponsor: Al-Azhar University

Brief Summary

This study was conducted to evaluate and compare the efficacy of Olinanoseal and Curodont D'Senz in treatment of dentin hypersensitivity.

Detailed Description

Materials and Methods:- A total of ninety (90) samples were used in the study, for dentin permeability test (dye penetration test) and Scanning Electron Microscopic examination (SEM) which were randomly divided into two main groups; group A1, completely removed smear layer, group A2, partially removed smear layer. Each group was subdivided into three subgroups according to the desensitizing agent applied: OliNano SEAL, Curodont D'Senz and the control group that were left untreated. Seventy (70) hypersensitive teeth in ten patients were enrolled for the current study. The subjective assessment of dentin hypersensitivity was done prior to the application of the desensitizing agent (baseline) then immediately, 2 weeks, 4 weeks and 3 months after application of the tested materials. Patients were informed to rate their perception to tactile, air and cold stimuli by using Verbal Rating Score (VRS) and Visual Analogue Scale (VAS).

Study Timeline

• Study Start: 2020-04-20
• Primary Completion: 2020-11-23
• Study Completion: 2021-01-12
• Study First Submitted: 2021-03-17
• Status Verified: 2021-11
• Study First Submitted QC: 2021-11-14
• Last Update Submitted: 2021-11-14
• Study First Posted: 2021-11-16
• Last Update Posted: 2021-11-16

Recruitment & Eligibility

• Status: COMPLETED
• Sex: Female
• Target Recruitment: 70

Inclusion Criteria

1. Presence of a minimum of four hypersensitive teeth in each patient.
2. Patients with teeth recorded a discomfort score of two or more to tactile, cold and air stimulation.
3. Teeth having hypersensitivity only on the facial aspect.
4. Patients' willingness to participate in the study

Exclusion Criteria

1. Patients with any medical or dental condition that could impact the study results during its expected length.
2. Patients with a history of drug addictions and use of potent analgesic and/ or anti-inflammatory drugs.
3. Patients who refused to give their consents.
4. Patients with any extensive or unsatisfactory restorations, prosthesis or orthodontic appliances which involve the cervical areas

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: PARALLEL

Arm && Interventions

Group	Intervention	Description
Totally removed smear layer	Olinanoseal	Smear layer is completely removed by etchant of phosphoric acid
Partially removed smear layer	Olinanoseal	Smear layer is partially removed by etchant of phosphoric acid
Totally removed smear layer	Curodont D'senz	Smear layer is completely removed by etchant of phosphoric acid
Partially removed smear layer	Curodont D'senz	Smear layer is partially removed by etchant of phosphoric acid

Primary Outcome Measures

Name	Time	Method
dentin hypersensitivity	3 months	pain score (visual analogue scale VAS \["minmum =0 {best}, maximum=10 {worst}\] and verbal rating scale VRS \["minmum =0 {best}, maximum=4 {worst}\])

Trial Locations

Locations (1)

Faculty of dental Medicine for girls, Al-AZhar University; 🇪🇬 Cairo, Egypt