The effect of prebiotic supplementation on asthma

Not Applicable

• Conditions: Asthma; Respiratory

• Registration Number: ISRCTN14120894
• Lead Sponsor: ottingham Trent University

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2021-05-19
• Last Update Posted: 7 June 2021
• Study Completion: 2023-09-01

Recruitment & Eligibility

• Status: Ongoing
• Sex: All
• Target Recruitment: 15

Inclusion Criteria

1. Aged 18-50 years of age
2. Body mass index (BMI) of 18.5-35 kg·m²
3. Non-smoker
4. Asthma severity defined as Steps 1 to 5 based on British Thoracic Society guidelines
5. Current asthma diagnosis and medication prescription from GP (e.g. maintenance and reliever inhalers)
6. In the researcher’s opinion, able and willing to follow all the trial requirements
7. Potential participants must disclose any nutritional supplements they take to the researcher, to determine whether these may be considered as exclusion criteria

Exclusion Criteria

1. Suffer from asthma but do not have a current medication prescription from GP (e.g. maintenance and reliever inhalers)
2. Regularly consume Omega-3 supplements, and/or eat high levels of Omega-3 (e.g. more than 1-2 portions of oily fish such as salmon or mackerel a week).
3. Take aspirin or other non-steroidal anti-inflammatory drugs such as ibuprofen once a day on 5 of the 7 days of the week
4. Females only: pregnant or planning a pregnancy during the time of the study (on each visit participants will be asked to complete a pregnancy test if within childbearing age)
5. Consumed prebiotics and/or probiotics (supplements), drugs that affect gastrointestinal mobility or laxatives in the 4 weeks before signing the consent form
6. Vegetarian or vegan diet
7. Previously diagnosed with chronic obstructive pulmonary disease (COPD), emphysema, chronic bronchitis, or similar respiratory (breathing-related) illness
8. Admitted to hospital during the past 12 months for asthma
9. History of heart failure, pulmonary hypertension, embolism, or other pulmonary heart disease
10. History of recurrent chest infections
11. Acute infection in the last 4 weeks and/or major operation in the past 4 months
12. History of gastrointestinal drug reaction
13. Taken antibiotics in the past 3 months
14. History or current evidence of gastrointestinal disease (e.g. chronic constipation, diarrhoea, irritable bowel syndrome, Crohn’s disease)
15. Recently taken part in other research projects. Please notify the chief investigator
16. Are or believe they may be lactose intolerant
17. Regularly take antioxidant supplements, such as beta-carotene, vitamin A, vitamin C, vitamin E, lutein and selenium
18. Standard multivitamin and mineral supplements are acceptable; however, If a single antioxidant supplement (e.g. Vitamin C) is more than the recommended daily Dietary Reference Values (DRVs) this must be checked with the chief investigator

Study & Design

• Study Type: Interventional
• Study Design: Not specified