Influence of Hesperidin and Vitamin C on Uric Acid Concentration
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- University of Kiel
- Enrollment
- 40
- Locations
- 1
- Primary Endpoint
- Changes in uric acid serum concentrations
Study Overview
Brief Summary
Aim of the study is to investigate the impact of hesperidin and/or vitamin C on elevated uric acid concentrations.
Detailed Description
Duration of the study is 9 weeks. 1) a washout week, 2) two intervention weeks, 3) four weeks washout period, 4) two intervention weeks.
The study is conducted under free living conditions. During washout weeks consumption of orange juice or citrus fruits or vitamin C containing supplements is restricted.
During intervention weeks 200 mL of study drink is consumed daily. And participants are asked to maintain their normal physical activity and habitual diet. Additional citrus or vitamin C containing beverages are not allowed.
At the beginning and the end of each intervention phase uric acid, insulin sensitivity, blood pressure, pulse wave velocity and bioavailability of hesperidin are assessed.
Study Design
- Study Type
- Interventional
- Allocation
- Randomized
- Intervention Model
- Crossover
- Primary Purpose
- Basic Science
- Masking
- Double (Participant, Investigator)
Eligibility Criteria
- Ages
- 20 Years to 80 Years (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •higher uric acid concentration (≥5.5 mg/dL)
- •Informed written consent
Exclusion Criteria
- •pregnancy
- •fructose intolerance
- •gout or medicated hyperuricemia
- •diabetes mellitus
- •antidiabetic or cytostatic medication
- •weight loss (≥5% in the past 3 months)
- •consumption of vitamin C-containing supplements
- •parallel participation in a clinical trial
- •anemia and / or iron deficiency
Arms & Interventions
Hesperidin (A)
study drink without hesperidin and without vitamin C compared to study drink with hesperidin
Intervention: Control (Dietary Supplement)
Hesperidin + Vitamin C (B)
study drink with vitamin C compared to study drink with hesperidin and vitamin C
Intervention: Hesperidin + Vitamin C (Dietary Supplement)
Hesperidin + Vitamin C (B)
study drink with vitamin C compared to study drink with hesperidin and vitamin C
Intervention: Vitamin C (Dietary Supplement)
Hesperidin (A)
study drink without hesperidin and without vitamin C compared to study drink with hesperidin
Intervention: Hesperidin (Dietary Supplement)
Outcomes
Primary Outcomes
Changes in uric acid serum concentrations
Time Frame: Baseline (pre) and post two weeks of intervention
measured via uric acid serum concentration (mg/dL)
Secondary Outcomes
- changes in pulse wave velocity(Baseline (pre) and post two weeks of intervention)
- insulin sensitivity(Baseline (pre) intervention periods)
- changes in uric acid excretion(Baseline (pre) and post two weeks of intervention)
Investigators
Prof. Dr. Dr. Anja Bosy-Westphal
Prof. Dr. Dr. Anja Bosy-Westphal
University of Kiel