The effect of an outpatient exercise training rehabilitation programme on haemodynamics and cardiac magnetic resonance parameters of right ventricular function in patients with pulmonary arterial hypertension: the ExPAH trial.

Not Applicable

Recruiting

• Conditions: Pulmonary arterial hypertension; Cardiovascular - Diseases of the vasculature and circulation including the lymphatic system

• Registration Number: ACTRN12615001041549
• Lead Sponsor: St Vincent's Hospital Sydney.

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Study Start: 2015-10-07
• Last Update Posted: 12 July 2021

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 52

Inclusion Criteria

Pulmonary arterial hypertension, functional class I-III.

Exclusion Criteria

Change in PAH specific medication in preceding 3 months.
Enrolment in formal exercise program in preceding 3 months.
Pregnancy.
Unable to follow instructions.
Patients with significant unstable cardiac disease (e.g. unstable angina).
Patients who are unable to have MRI (impaired renal function, permanent pacemaker etc).

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Right ventricular ejection fraction on cardiac MRI.[3 months post start of intervention (exercise).]

Secondary Outcome Measures

Name	Time	Method
Haemodynamics, measured by right heart catheterisation at rest, and during exercise in the sub-study participants.[3 months post start of intervention.];Exercise capacity measured by 6MWT.[3 months post start of intervention and 6 months post start of intervention.];Quality of Life measured by CAMPHOR, DASS 21 and Lawton's Instrumental Activities of Daily Living.[3 and 6 months post start of intervention.];Muscle strength, tested by grip strength.[3 and 6 months post start of intervention.];Bio markers of cardiac function, measured by NT-proBNP, IL6.[3 and 6 months post start of intervention.]