Craniosynostosis : Surgical Treatment Modalities and Outcome
试验速览
- 阶段
- 不适用
- 入组人数
- 24
- 主要终点
- Cosmosis
研究概览
简要总结
Aim of study:
- To evaluate outcome of cases( cosmoses and cognition) after Craniosynostosis surgery
-
- To ascertain intra- and postoperative complications
详细描述
Craniosynostosis is defined as the premature fusion of one or more of the sutures normally separating the infant's skull bony plates, resulting in abnormal growth of the cranial vault and skull base, which may influence brain growth and development(1).
Aetiology Primary Craniosynostosis: No cause for the synostosis is recognized in the majority of cases, , but in an increasing proportion (currently about 25%), a mutation is identified. A considerable proportion of these mutations are related to six genes FGFR2, FGFR3, TWIST1, EFNB1, TCF12 and ERF(2).
Types of Craniosynostosis Non-syndromic (or isolated), in which only the skull is affected, The syndromic craniosynostosis is caused by an inherited or genetic condition and associated with craniofacial syndromes(3).
Syndromic craniosynostosis is most commonly found in:
- Apert syndrome
- Crouzon syndrome
- Muenke syndrome
- Pfeiffer syndrome
- Saethre-Chotzen syndrome(4)
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 3 Months 至 8 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •all patients either syndromic or nonsyndromic
排除标准
- •• Patients aged less than 3 month
- •Patients had bad general condition
结局指标
主要结局
Cosmosis
时间窗: 1 year
cosmosis of patients after Craniosynostosis surgery by these measures : Cephalic index
次要结局
- intraoperative bleeding(1 year)
研究者
Mohamed Amgad Kotb
Craniosynostosis: surgical treatment modalities and outcome
Assiut University