Immediate antidepressant response of oral ketamine versus IV ketamine in depressio
Phase 3
Completed
- Conditions
- Health Condition 1: F322- Major depressive disorder, singleepisode, severe without psychotic features
- Registration Number
- CTRI/2020/09/027644
- Lead Sponsor
- Dr P N Suresh Kumar
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 61
Inclusion Criteria
1 Failed 2 trial of different antidepressant class of adequate dose and duration.
2 Current depressive episode is of at least 4 weeks duration.
3 Not received ECT at least prior to enrollment.
Exclusion Criteria
1 Other psychiatric disorders.
2 Pregnancy and lactation.
3 Concurrent major life-threatening illness like malignancy, cardiac failure, renal failure etc.
4 Alcohol and substance abuse and smokers.
5 Patients with electrocardiogram abnormality or abnormality on fundoscopy.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method change in clinical ratings of depression in Hamilton Depression Rating ScaleTimepoint: Day 0,3,5,7,9,11,13
- Secondary Outcome Measures
Name Time Method Changes in Montgomery Asberg Depression rating scale and Clinical Global Impression of severity and ImprovementTimepoint: Day 0,3,5,7,9,11,13 and 1 month