Correlation Between the Risk of Peri-Implantitis and Increased Levels of Proinflammatory Cytokines following an interaction between Titanium dioxide and Macrophages
- Conditions
- Peri-implantitis
- Registration Number
- DRKS00028653
- Lead Sponsor
- Mund-, Kiefer-, Gesichschirurgie (MKG) Universitätsklinik Hamburg-Eppendorf
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete
- Sex
- All
- Target Recruitment
- 60
20 patients without titanium implants in the jawbone
- 20 patients with at least one titanium implant in the jawbone without peri-implantitis
- 20 patients with at least one titanium implant in the jawbone with peri-implantitis or implant loss
Patients with titanium implants outside the jawbone and risk or high risk factors according to ITI-consensus-conference:
Risk factors:
- Radiated bone
- Inadequately controlled Diabetes mellitus (HbA1c > 7,5%)
- Hemorrhagic diathesis
- Antiresorptive therapies (bisphosphonates, denosumab)
- Smokers
- Poor oral hygiene (from grad 3 according to
Sillness and Löe)
High-risk factors
- Serious systemic diseases (e.g. leukemia, TBC)
- Immunocompromised patients (e.g. HIV)
- Drug abuse
- Mental altered patients
- Uncooperative patients
Study & Design
- Study Type
- observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method
- Secondary Outcome Measures
Name Time Method