Segmentation of Structural Abnormalities in Chronic Lung Diseases

Active, not recruiting

• Conditions: Asthma; Interstitial Lung Disease; Cystic Fibrosis; COPD

• Registration Number: NCT04760548
• Lead Sponsor: Hôpital Haut Lévêque

Brief Summary

Lung structural abnormalities are complex, time-consuming, and may lack reproducibility to evaluate visually on CT scans. The study's aim is to perform automated recognition of structural abnormalities in CT scans of patients with chronic lung diseases by using dedicated software.

Detailed Description

Three chronic lung diseases will constitute the target of the study, by using retrospective data from each lung disease:

* Cystic fibrosis

* Asthma and COPD

* Interstitial lung diseases

Dedicated algorithms will be developped for each disease condition.

Study Timeline

• Study Start: 2008-01-01
• Study First Submitted: 2021-02-15
• Study First Submitted QC: 2021-02-15
• Study First Posted: 2021-02-18
• Status Verified: 2023-09
• Last Update Submitted: 2023-12-31
• Last Update Posted: 2024-01-05
• Primary Completion: 2024-02-17
• Study Completion: 2024-02-17

Recruitment & Eligibility

• Status: ACTIVE_NOT_RECRUITING
• Sex: All
• Target Recruitment: 800

Inclusion Criteria

• Patients with chronic lung disease and clinical examination, pulmonary function test, and CT acquired during a routine follow-up

Exclusion Criteria

Not provided

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Validity of automated measurement	From date of inclusion until the date of final quantification, assessed up to 12 months	Correlations and comparisons with other biomarker of the disease severity

Secondary Outcome Measures

Name	Time	Method
Correlation with pulmonary function test	From date of inclusion until the date of final quantification, assessed up to 12 months	Correlation of quantitative measurement with pulmonary function
Reproducibility	From date of inclusion until the date of final quantification, assessed up to 12 months	Evaluation of measurements when performed twice
Longitudinal variation over time	From date of inclusion until the date of final quantification, assessed up to 12 months	Comparison of quantitative measurement at two time points

Trial Locations

Locations (1)

Hopital Haut Leveque; 🇫🇷 Pessac, France