A Pilot study of periodontopathic Bacterial Load suppression Efficacy Assessment of biofilm Cleaning in Healthy volunteers and patients with mild periodontitis
Not Applicable
- Conditions
- Healthy individuals
- Registration Number
- JPRN-UMIN000050521
- Lead Sponsor
- Aichi gakuin University
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up continuing
- Sex
- All
- Target Recruitment
- 10
Inclusion Criteria
Not provided
Exclusion Criteria
Patients who fall into any of the following criteria are excluded from participating in the study; 1. Individuals with smoking habit 2. Individuals who are taking medical agents due to diabetes mellitus, chronic renal disease, gastrointestinal disorder, pulmonary disease, malignant tumor, etc. 3. Individuals who routinely use products that inhibit periodontopathogenic bacteria, such as mouth wash agents 4. Individuals whose stimulant saliva is 3.0mL or less
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Amount and change of periodontopathogenic bacteria (P. gingivalis and F. nucleatum bacteria) in stimulated saliva measured by PCR invader method
- Secondary Outcome Measures
Name Time Method Measurement at each observation point and change from baseline to each observation point of following items; 1. Amount of periodontopathogenic bacteria (P. gingivalis and F. nucleatum bacteria) in stimulated saliva measured by PMA-qPCR method 2. Amount of other bacteria (Campylobacter concisus) in stimulated saliva 3. Characteristics of stimulated saliva (pH, amount) 4. Concentration of calprotectin in stimulated saliva 5. Concentration of vascular endothelial growth factor (VEGF) and human epidermal growth factor (hEGF) in stimulated saliva 6. clinical indicators (gingival index (GI), plaque index (PI), bleeding on probing (BOP), probing depth (PD), clinincal attachment level (CAL), and tongue coating score)