Effects of Magnesium Carbonate tablet on hyperphosphatemia in patients under hemodialysis

Phase 2

Conditions: Condition 1: End stage renal disease. Condition 2: hyperphosphatemia.
End Stage Renal Disease
classified in other phosphoru metabolism defect.
E83.39

Registration Number: IRCT201105186515N1

Lead Sponsor: Vice chancellor for research, Isfahan University of Medical Sciences

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Complete

Sex: All

Target Recruitment: 50

Inclusion Criteria

age>18 years; serum phosphorus >5.5 mg/dl; at least 3 months on hemodialysis.
exclusion criteria: serum magnesium > 4 mg/dl; pregnancy; previous parathyroidectomy; sever hyperparathyroidism(iPTH> 500 pg/ml); Medical disease cause diarrhea; Kidney transplant; Patient Death; Non-compliance of drug usage (at least 80% of prescribed drug must be used); Drug complications making the patient unable to continue the treatment; Lost hemodialysis more than one per month or Irregular hemodialysis

Exclusion Criteria

Not provided

Study & Design

Study Type: interventional

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Changes in serum phosphorus level. Timepoint: Before trial and every 2 weeks till at the end of 6the week. Method of measurement: Lab data mg/dl.;Changes in Ca X P product. Timepoint: Before trial then every 2 weeks till the end of 6th week. Method of measurement: Lab data mg/dl.;Changes in serum calcium. Timepoint: Before trial and every two weeks till the end of 6th week. Method of measurement: Lab data mg/dl.;Changes in serum magnesium. Timepoint: Before trial and every two weeks till the end of 6th week. Method of measurement: Lab data, mg/dl.

Secondary Outcome Measures

Name	Time	Method
Abdominal pain and diarrhea. Timepoint: Before trial then every 2 weeks till the end of 6th week. Method of measurement: Clinical data(history and examination).;Cardiac arhrythmia. Timepoint: Before trial then every 2 weeks till the end of 6th week. Method of measurement: Clinical data(history and examination) and electrocardiography.;Serum LDL, HDL, Tg, Chol,. Timepoint: Before trial then at the end of 6th week. Method of measurement: Lab data mg/dl.;PTH. Timepoint: Before trial then at the end of 6th week. Method of measurement: Lab data pg/ml.;CRP. Timepoint: before trial then every 2 weeks till the end of 6th week. Method of measurement: lab data mg/l.;Serum HCo3. Timepoint: Before trial then every 2 weeks till the end of 6th week. Method of measurement: Lab data mmol/l.;Blood pressure. Timepoint: Before trial then every 2 weeks till the end of 6th week. Method of measurement: Clinical data(examination) mmHg.