Characteristics of Infective Endocarditis in East China

Completed

• Conditions: Infective Endocarditis
• Interventions: Other: no intervention

• Registration Number: NCT04977518
• Lead Sponsor: Second Affiliated Hospital, School of Medicine, Zhejiang University

Brief Summary

This was a retrospective observational study of consecutive cases of definite or possible infective endocarditis (IE) as per the modified Duke criteria between January 2008 and December 2015, which was performed at the Second Affiliated Hospital of Zhejiang University, School of medicine (SAHZU), a tertiary care referral hospital located in East China.

Detailed Description

Infective endocarditis (IE) is a rare but life-threatening serious disease that still has a high mortality, even in developed countries. The objective of this study was to evaluate the clinical presentations, treatment and outcomes of IE patients in a tertiary hospital in East China over an 8-year period. This was a retrospective observational study of consecutive cases of definite or possible IE as per the modified Duke criteria between January 2008 and December 2015.

Study Timeline

• Study Start: 2008-01-01
• Primary Completion: 2015-12-31
• Status Verified: 2016-03
• Study Completion: 2016-10-20
• Study First Submitted: 2021-07-13
• Study First Submitted QC: 2021-07-26
• Last Update Submitted: 2021-07-26
• Study First Posted: 2021-07-27
• Last Update Posted: 2021-07-27

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 183

Inclusion Criteria

• Patients with a clinical diagnosis of infective endocarditis.

Exclusion Criteria

• Patients did not meet the modified Duke criteria.

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients diagnosed during 2008-2011	no intervention	Patients diagnosed with definite and probable infective endocarditis defined according to the modified Duke clinical criteria during 2008-2011
Patients diagnosed during 2012-2015	no intervention	Patients diagnosed with definite and probable infective endocarditis defined according to the modified Duke clinical criteria during 2012-2015

Primary Outcome Measures

Name	Time	Method
Complications (neurological events, systemic embolism, and congestive heart failure) of infective endocarditis	During the hospitalization, average of 1 months	1. A neurological event was defined as symptomatic or asymptomatic stroke, hemorrhage, or encephalopathy.; 2. Systemic embolization was defined as an embolic event outside of the central nervous system.; 3. Congestive heart failure was defined as with class III, or IV heart failure and an ejection fraction of 40% or less.
Mortality	During the hospitalization, average of 1 months	Patients dead or moribund before discharge