Infections and Latent Autoimmune Diabetes in Adults
- Conditions
- Latent Autoimmune Diabetes in AdultsType 2 Diabetes
- Registration Number
- NCT06167616
- Lead Sponsor
- Karolinska Institutet
- Brief Summary
Infections are proposed risk factors for type 1 diabetes in children. The investigators will examine whether a diagnosis of infectious disease also confers an increased risk of latent autoimmune diabetes in adults.
- Detailed Description
The investigators will use data from a population-based Swedish case-control study (ESTRID) with incident cases of LADA (n=597) and matched controls (n=2386). History of infectious disease are ascertained through national and regional patient registers. The investigators will estimate adjusted odds ratios (OR) with 95% CI for ≥1 respiratory (any/upper/lower), gastrointestinal, herpetic, other or any infectious disease episode, or separately, for 1 and ≥2 infectious disease episodes, within 0-1, 1-3, 3-5 and 5-10 years before LADA diagnosis/matching. Stratified analyses will be performed based on HLA risk genotypes and GADA levels.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 5048
- 35 years or older, residing in Scania or Uppsala county.
- Less than 35 years
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method LADA Up to 10 years ≥35 years at diagnosis, GADA positivity (≥10 U/ml) and C-peptide concentrations of ≥0.2 nmol/L (IMMULITE) or ≥0.3 nmol/L (Cobas).
- Secondary Outcome Measures
Name Time Method Type 2 diabetes Up to 10 years also ≥35, GADA negative and had C-peptide concentrations of \>0.60 (IMMULITE)/\>0.72 (Cobas) nmol/L.
Trial Locations
- Locations (1)
Karolinska institute
🇸🇪Stockholm, Sweden