Use of Biomarkers in Early Surgery Patients to Determine Effectiveness of Regional Acceleratory Phenomenon and Its Effect on Root Resorption
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Class III Malocclusion
- Sponsor
- Bezmialem Vakif University
- Enrollment
- 13
- Locations
- 1
- Primary Endpoint
- Assessing Change Between Two Time Points to Determine Root Resorption
- Status
- Completed
- Last Updated
- 5 years ago
Overview
Brief Summary
A prospective clinical trial to what extent inflammatory biomarkers are affected by the medication after orthognathic surgery in early surgical cases and whether these biomarkers affects the amount of maxillary or mandibular incisor root resorption.
Detailed Description
To conduct a prospective clinical trial to what extent inflammatory biomarkers such as OPG, RANKL, IL-1, IL-6, and CRP are affected by the medication after orthognathic surgery in early surgical cases and whether these biomarkers affects the amount of maxillary or mandibular incisor root resorption.
Investigators
Eligibility Criteria
Inclusion Criteria
- Not provided
Exclusion Criteria
- •ongoing use of regular medication
- •known penicillin allergy,
- •any immune disorder,
- •musculoskeletal diseases,
- •cleft lip-palate,
- •systemic diseases affecting root resorption,
- •periodontal and gingival disorders,
- •missing teeth among upper or lower incisors,
- •poor oral hygiene.
Outcomes
Primary Outcomes
Assessing Change Between Two Time Points to Determine Root Resorption
Time Frame: To see the change of root length all radiographs were taken digitally at t0 (at the beginning of orthodontic preparation), t1 (just before the orthognathic surgery), and t2 ( an average of 1,5 years postop) with an X-ray unit
Morphologic changes in root apex
Assessing Change Between Three Time Points of Biomarkers to Determine Effectiveness of Regional Acceleratory Phenomenon
Time Frame: To see the change at biomarker levels GCF samples were collected at the time points designated as T0, T1, and T2 which correspond to the day of the surgery before anesthesia, 1 week after the surgery, and 4 weeks after the surgery
IL- 6 RANKL