Allergens in Inner-City Schools and Childhood Asthma
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 351
- 试验地点
- 1
- 主要终点
- Maximum Symptom Days/14 Days
研究概览
简要总结
Asthma is a disease that affects more than 12% of Americans under the age of 18 for over 14 million missed school days per year, and is the number one cause of school absences in America. Elementary school children spend 6 to 10 hours a day in school, and most of that time is spent in one classroom. The goals of this project are to provide an understanding of exposure risk factors specific to the classroom. This is critical, because the classroom environment could potentially be considered as an effective target for prevention of inner-city asthma morbidity by reducing exposures to many symptomatic children through an intervention in the school classrooms.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 4 Years 至 15 Years（Child）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •Grades K-8 the school year following spring recruitment (Ages 4-15)
- •Attend one of the schools in the fall where permission obtained for classroom sampling.
- •Able to provide assent and parent/guardian able to provide informed consent Physician-Diagnosed asthma AND Wheezing in the previous 12 months
排除标准
- •Significant pulmonary diseases other than asthma that might influence test results or pose risks (e.g., cystic fibrosis, sarcoidosis, bronchiectasis)
- •Cardiovascular disease that requires daily medication
- •Taking a beta blocker
- •Active smoker
- •Unable to follow through with study visit or complete study procedures
结局指标
主要结局
Maximum Symptom Days/14 Days
时间窗: 14 days
Largest value among the following: Number of days with wheezing, tightness in the chest, or cough Number of nights with disturbed sleep as a result of asthma Number of days on which the child had to slow down or discontinue play activities because of asthma
次要结局
- Days of Slowed Activity Due to Asthma(12 months)
- Days of Exercise-induced Symptoms(12 months)
- Days of Cough Without an Upper Respiratory Infection(12 months)
- Nights of Wakening Due to Asthma Symptoms(12 months)
- Number of Hospitalizations(12 months)
- Emergency Department Visits(12 months)
- Unscheduled Physician/Health Care Visits(12 months)
- Prednisone Bursts(12 months)
- FEV1/FVC(12 months)
- FEV1 Percent Predicted(12 months)
- Percent Change in FEV1 After Short-acting Beta Agonist(12 months)
- Exhaled Nitric Oxide Levels(12 months)
研究者
Wanda Phipatanakul
Associate Professor of Pediatrics
Boston Children's Hospital